Unravelling cell wall polysaccharide biosynthesis in pathogenic zygomycetes

揭示致病接合菌细胞壁多糖的生物合成

• 批准号: DP210103779
• 负责人: Prof Vincent Bulone
• 金额: $ 35.39万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103779
• 关键词: Unravelling; cell; wall; polysaccharide; biosynthesis

This project aims to define mechanisms that control cell wall composition and stability in Rhizopus oryzae, a zygomycete fungus responsible for life-threatening human infections. The biochemical properties and function of vital enzymes involved in a newly discovered cell wall polysaccharide biosynthetic pathway will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology and structural biology. Expected outcomes include new knowledge on the enzymes that synthesise major fucose-based carbohydrates, to guide the future development of novel strategies for antifungal therapies. The data will also be applicable to animal protection from related zygomycete pathogens.

该项目旨在确定控制米根霉（Rhizopus oryzae）细胞壁组成和稳定性的机制，米根霉是一种接合菌，可导致危及生命的人类感染。新发现的细胞壁多糖生物合成途径中涉及的重要酶的生化特性和功能将利用生物化学、微生物学、细胞生物学和结构生物学交叉领域的创新方法来确定。预期成果包括合成主要岩藻糖碳水化合物的酶的新知识，以指导抗真菌治疗新策略的未来发展。该数据也将适用于动物保护免受相关接合菌病原体的侵害。