Cellular organization in the hippocampal formation
海马结构中的细胞组织
基本信息
- 批准号:09480213
- 负责人:
- 金额:$ 8.51万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:1997
- 资助国家:日本
- 起止时间:1997 至 1999
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Neuronal organization of the hippocampal formation is traditionally based on the neuronal types defined by classical morphological method such as Golgi impregnation. However recent progress in immunocytochemistry and other methods revealing chemical nature of neuronal elements makes it possible to define chemical subpopulations of neurons, which are not necessarily corresponding to classical morphologically defined neuronal types. In the present project we are intending combined light and electron microscopic analyses of immunocytochemically defined neurons in the hippocampal formation. In this project we concentrated on two topics, quantitative analysis of GABAergic neurons in the hippocampus in the rat and mouse, and characterization of some types of neurons containing calcium binding proteins such as parvalbumin and calretinin. The numbers of chemically defined neurons in the rat and mouse hippocampii have been estimated by a stereological method, optical disector, which revealed th … More e GABAergic neuronal organization of each region and layer in the hippocampus. The areal and laminar distribution of each group of cells shows prominent differences, indicating that the cellular composition was different among regions and from layer to layer. In addition to quantitative disector analyses, we also notice followings ;1) There are astonishing species differences in the calretinin immunoreactivity of the principal neurons of the dentate hilus, mossy cells, which were calretinin positive at the ventral level in the mouse, hamster, gerbil and laboratory shrew whereas they were negative in rat and guinea pig. However, at the dorsal level mossy cell were calretinin negative even in the mouse, hamster, gerbil and laboratory shrew, showing prominent dorsoventral difference in their chemical properties.(2) Parvalbumin containing GABAergic neurons were revealed to make numerous chemical synapses and gap junctions with one another, indicating dual interactions among them and their presumed critical roles in the hippocampal gamma synchronized oscillation. Less
海马形成的神经元组织传统上是基于通过经典形态学方法(例如高尔基体浸渍)定义的神经元类型。但是,免疫细胞化学和其他揭示神经元元素的化学性质的方法的最新进展使得定义神经元的化学亚群,这不一定与经典的形态学定义的神经元类型相对应。在目前的项目中,我们是海马形成中免疫细胞化学定义神经元的旨在合并的光和电子显微镜分析。在这个项目中,我们集中在两个主题上,对大鼠和小鼠海马中的GABA能神经元进行定量分析,以及对某些类型的含有钙结合蛋白的神经元(如白蛋白和calletin)的表征。通过一种立体论方法估算了大鼠和小鼠海马中化学定义的神经元的数量,光学谱图揭示了每个区域的更多e Gabaergic神经元组织,并在海马中层。每组细胞的面积和层流分布都显示出明显的差异,表明细胞组成在区域之间以及层之间都不同。除了定量二元分析外,我们还注意到以下; 1)齿状hilus的主要神经元的calletin免疫反应性存在惊人的物种差异,苔藓细胞,苔藓细胞在小鼠,hamster,gerbil和Laboration shrew and and ane eyea and yealea pighea and and and andea is calletin呈阳性。然而,在背层的苔藓细胞中,即使在老鼠,仓鼠,沙鼠和实验室中,也显示出其化学特性的明显背腹差异。(2)含有含有gabaga能神经元的白蛋白素的背腹差异,以使其与另一种化学突触和差异相互作用,并与它们相互作用,并在其上进行了批判性的症状,并与他们的差异进行了批判性互动,并构成了杂物症状,并构成了杂物症状,并构成了杂物症状,并构成了杂物症状,并构成了杂物症状的杂物。同步振荡。较少的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
H. -D. Wang, T. Fukuda, T. Suzuki. K. Hashimoto, S. -Y. Lion, T. Momoi, T. Kosaka, K. Yamamoto and H. Nakanishi: "Differential effects of Bcl-2 overexpression on hippocampal Cal neurons and dentate granule cells following hypoxic ischemia in adult mice"Jo
高清。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
T. Fukuda, H. Wang, H. Nakanishi, K. Yamamoto and T. Kosaka: "Novel non-apoptotic morphological changes in neurons of the mouse hippocampus following transient hypoxicishemia"Neuroscience Research. 33. 49-55 (1999)
T. Fukuda、H. Wang、H. Nakanishi、K. Yamamoto 和 T. Kosaka:“短暂性低氧血症后小鼠海马神经元的新型非凋亡形态变化”神经科学研究。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
S. Jinno: "Quantitative analysis of neuronal nitric oxide synthase-immunoreactive neurons in the mouse hoppocampus with optical disector."Journal of Comparative Neurology. 410. 398-412 (1999)
S. Jinno:“用光学解剖器对小鼠海马中神经元一氧化氮合酶免疫反应性神经元进行定量分析。”比较神经病学杂志。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
T. Fukuda and T. Kosaka: "Gap junctions linking the dendritic network of GABAergic interneurons in the hippocampus"J. Neurosci.. 20(in press). (2000)
T. Fukuda 和 T. Kosaka:“连接海马 GABA 能中间神经元树突网络的间隙连接”J。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
N.FUJISE: "Mossy ceiis the mouse dentate gyrus:identification in the dorsal hilus and their distribution along the dorsoventral axis" Brain Resesrch. 816. 500-511 (1999)
N.FUJISE:“苔藓脑是小鼠齿状回:背门的识别及其沿背腹轴的分布”大脑研究。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
KOSAKA Toshio其他文献
KOSAKA Toshio的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('KOSAKA Toshio', 18)}}的其他基金
The neuronal organization of the olfactory bulb revisited
重新审视嗅球的神经元组织
- 批准号:
23300124 - 财政年份:2011
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analyses on the cellular and synaptic organization of the olfactory bulb and related higher olfactory centers
嗅球及相关高级嗅觉中枢的细胞和突触组织分析
- 批准号:
20300120 - 财政年份:2008
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Structural analyses of the cellular and synaptic organization in the cortical regions in mice.
小鼠皮质区域细胞和突触组织的结构分析。
- 批准号:
17300112 - 财政年份:2005
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Quantitative and three-dimensional structural analyses of neurons and glia in various cortical regions in mice, rats and some other mammals.
对小鼠、大鼠和其他一些哺乳动物的各个皮质区域的神经元和神经胶质细胞进行定量和三维结构分析。
- 批准号:
13480251 - 财政年份:2001
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of the basic system for the stereological analysis in the brain
大脑体视分析基本系统的开发
- 批准号:
05558093 - 财政年份:1993
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
GABAergic neurons in the central nervous system
中枢神经系统中的 GABA 能神经元
- 批准号:
04404022 - 财政年份:1992
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for General Scientific Research (A)
Chemically Defined Subpopulations of GABAergic Neurons in the Cerebral cortex.
大脑皮层中 GABA 能神经元的化学定义亚群。
- 批准号:
01480113 - 财政年份:1989
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
GABAergic neurons in the hippocampus and dentate gyrus.
海马和齿状回中的 GABA 能神经元。
- 批准号:
60570031 - 财政年份:1985
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似海外基金
The role of calcuim-binding protein in acute pancreatitis: aiming for a new drug discovery
钙结合蛋白在急性胰腺炎中的作用:旨在发现新药
- 批准号:
16K09401 - 财政年份:2016
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (C)