Corticosteroid irrigation of parotid gland for treatment of xerostomia in patients with Sjogren's syndrome

腮腺皮质类固醇冲洗治疗干燥综合征患者口干症

• 批准号: 09671927
• 负责人: IZUMI Masahiro
• 金额: $ 2.05万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671927/
• 关键词: Sjogren's syndrome; MRI; fat deposition; xerostomia; corticosteroids; treatment; シェ-グレン症候群

The purpose of this study was to determine the efficacy of corticosteroid irrigation of the parotid gland in relieving salivary flow deficiency in patients with Sjogren's syndrome.The parotid glands of thirty-nine patients with primary (twenty nine) or secondary (ten) Sjogren's syndrome were irrigated either with saline solution followed by corticosteroid solution. Salivary function was assessed by Saxon test.Corticosteroid irrigation significantly increased the salivary flow rate in patients with Sjogren's syndrome (p< 0.0001), with clinical improvement detectable 4.0 "*" 2.6 weeks after initial corticosteroid irrigation. The extent of improvement in salivary function was reciprocal to the clinical severity of the disease, with patients at the early stages obtaining 1.20*0.57 g net increase in salivary flow rate, and patients at the most advanced stages obtaining 0.20 "*" 0.47 g net increase. Repeated steroid irrigations did not evoke steroid refractoriness of the salivary gland ; similar levels of net increase in salivary flow rate were observed after the second to fourth challenge of the corticosteroid in these patients. The sustained period was 8.6 months.These findings suggest the clinical usefulness of corticosteroid irrigation therapy in relieving xerostomia in patients with Sjogren's syndrome.

这项研究的目的是确定腮腺皮质类固醇激素灌溉在缓解Sjogren综合征患者的唾液流量缺乏方面的功效。三十九名基本（二十九个）或中次（十个）Sjogren综合征的核腺与c conteroid一起使用。通过萨克森测试评估唾液功能。皮质类固醇激素灌溉显着增加了Sjogren综合征患者的唾液流量（P <0.0001），并在初始皮质类固醇灌溉后可检测到临床改善4.0“*”*2.6周。唾液功能的改善程度与该疾病的临床严重程度相互互补，在早期阶段的患者获得了1.20*0.57 g唾液流量的净增加，并且在最先进的阶段获得0.20“*” 0.47 g净净增加的患者。重复的类固醇灌溉没有引起唾液腺的类固醇折射率。在这些患者的第二到第四次挑战之后，观察到唾液流量的净增加水平相似。持续时间为8.6个月。这些发现表明皮质类固醇灌溉疗法在减轻术综合征患者的静态疗法方面具有临床实用性。

项目成果

M.Izumi, K.Eguchi, H.Nakamura, Y.Takagi, Y.Kawabe, T.Nakamura: "Corticosteroid irrigation of parotid gland for treatment of xerostomia in patients with Sjogren's syndrome." Ann Rheum Dis. 57. 464-469 (1998)

M.Izumi、K.Eguchi、H.Nakamura、Y.Takagi、Y.Kawabe、T.Nakamura：“腮腺皮质类固醇冲洗用于治疗干燥综合征患者的口干症。”

Izumi M.,他6名: "MR features of the lacrimal gland in Sjogren's syndrome" AJR. 170. 1661-1666 (1998)

Izumi M. 和其他 6 人：“干燥综合征泪腺的 MR 特征”AJR 170. 1661-1666 (1998)。

M.Izumi, K.Eguchi, H.Nakamura, S.Nagataki, T.Nakamura: "Premature fat deposition in salivary glands affected by Sjogren's syndrome : Evidence by MR and CT." AJNR. 18. 951-958 (1997)

M.Izumi、K.Eguchi、H.Nakamura、S.Nagataki、T.Nakamura：“受干燥综合征影响的唾液腺过早脂肪沉积：MR 和 CT 证据。”

Izumi M.,他4名: "Premature fat deposition in salivary glands affected by Sjogren´s syndrome ; Evidence by MR and CT" AJNR. 18. 951-958 (1997)

Izumi M. 和其他 4 人：“受干燥综合征影响的唾液腺过早脂肪沉积；MR 和 CT 证据”AJNR。18. 951-958 (1997)

Izumi M.,他4名: "Premature fat deposition in salivary glands affected by Sjogren's syndrome;Evidence by MR and CT" AJNR. 18. 951-958 (1997)

Izumi M. 和其他 4 人：“受干燥综合征影响的唾液腺中的过早脂肪沉积；MR 和 CT 的证据”AJNR。18. 951-958 (1997)