Corticosteroid irrigation of parotid gland for treatment of xerostomia in patients with Sjogren's syndrome

腮腺皮质类固醇冲洗治疗干燥综合征患者口干症

基本信息

批准号：
09671927
负责人：
IZUMI Masahiro
金额：
$ 2.05万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671927/
关键词：
Sjogren's syndrome MRI fat deposition xerostomia corticosteroids treatment シェ-グレン症候群

项目摘要

The purpose of this study was to determine the efficacy of corticosteroid irrigation of the parotid gland in relieving salivary flow deficiency in patients with Sjogren's syndrome.The parotid glands of thirty-nine patients with primary (twenty nine) or secondary (ten) Sjogren's syndrome were irrigated either with saline solution followed by corticosteroid solution. Salivary function was assessed by Saxon test.Corticosteroid irrigation significantly increased the salivary flow rate in patients with Sjogren's syndrome (p< 0.0001), with clinical improvement detectable 4.0 "*" 2.6 weeks after initial corticosteroid irrigation. The extent of improvement in salivary function was reciprocal to the clinical severity of the disease, with patients at the early stages obtaining 1.20*0.57 g net increase in salivary flow rate, and patients at the most advanced stages obtaining 0.20 "*" 0.47 g net increase. Repeated steroid irrigations did not evoke steroid refractoriness of the salivary gland ; similar levels of net increase in salivary flow rate were observed after the second to fourth challenge of the corticosteroid in these patients. The sustained period was 8.6 months.These findings suggest the clinical usefulness of corticosteroid irrigation therapy in relieving xerostomia in patients with Sjogren's syndrome.

这项研究的目的是确定腮腺皮质类固醇灌溉在减轻sjogren综合征患者的唾液流量缺乏方面的功效。三十九名原发性（二十九个）或次生（十个）Sjogren综合症患者的腮腺患者的粒细胞腺体是用盐溶液灌溉，然后用皮质类固醇溶液灌溉。通过萨克森测试评估唾液功能。皮质类固醇激素灌溉显着增加了Sjogren综合征患者的唾液流量（P <0.0001），并在初始皮质类固醇灌溉后可检测到临床改善4.0“*”*2.6周。唾液功能的改善程度与该疾病的临床严重程度相互互补，在早期阶段的患者获得唾液流量的净增加1.20*0.57 g净增加，并且在最先进的阶段的患者获得0.20“*” 0.47 g净净净。增加。重复的类固醇灌溉没有引起唾液腺的类固醇折射率。在这些患者的第二到第四次挑战之后，观察到唾液流量的净增加水平相似。持续时间为8.6个月。这些发现表明皮质类固醇灌溉疗法在减轻术综合征患者的静态疗法方面具有临床实用性。