Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During Puberty

青春期代谢综合征定量 MRI 生物标志物的演变

• 批准号: 8927626
• 负责人: Scott B. Reeder
• 金额: $ 18.55万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8927626
• 关键词: Abdomen; Address; Adipose tissue; Affect; Appointment; Area; Award; Biological Markers; Biomedical Engineering; Body mass index; Cardiovascular Diseases; Child; Childhood; Cirrhosis; Clinical; Clinical Oncology Supplement (K12); Clinical Research; Collaborations; Communities; Data; Deposition; Development; Development Plans; Diabetes Mellitus; Diagnosis; Diffuse; Disease; Doctor of Philosophy; Early Diagnosis; Emergency Medicine; Endocrinology; Environment; Ethnic Origin; Evolution; Faculty; Fatty acid glycerol esters; Fellowship; Fostering; Funding; Future; Goals; Gonadal Steroid Hormones; Health; Hematology; Hepatology; Hour; Image; Insulin Resistance; Interdisciplinary Study; Investigation; Ionizing radiation; Iron Overload; K-Series Research Career Programs; Lead; Leadership; Liver; Liver diseases; Magnetic Resonance Imaging; Measures; Medical; Medical Students; Medicine; Mentors; Mentorship; Metabolic; Metabolic syndrome; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Operative Surgical Procedures; Outcomes Research; Overweight; Patient-Focused Outcomes; Patients; Physician Executives; Physics; Physiological; Play; Portal Hypertension; Postdoctoral Fellow; Program Development; Puberty; Race; Radiology Specialty; Reproducibility; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Scanning; School-Age Population; Scientist; Serum; Serum Markers; Site; Somatotropin; Staging; Time; Training; Training Programs; Transaminases; Translations; Transplantation; United States National Institutes of Health; Universities; Validation; Vascular Diseases; Visceral; Visit; Wages; Wisconsin; Women' s Health; Work; abdominal fat; base; career; career development; clinical practice; clinically relevant; critical period; design; ethnic difference; girls; graduate student; health disparity; hemodynamics; high risk; improved; insight; liver imaging; liver injury; non-alcoholic fatty liver; nonalcoholic steatohepatitis; obesity in children; patient oriented; patient oriented research; premature; professor; programs; research and development; research study; subcutaneous; tool; waist circumference; young adult

DESCRIPTION (provided by applicant): This is a new submission for a K24 mid-career investigator award in patient-oriented research to support the mentoring, research and career development activities of Dr. Scott Reeder. Dr. Reeder is an Associate Professor at the University of Wisconsin-Madison, with a primary appointment in Radiology and cross- appointments in the Departments of Medicine, Medical Physics, and Biomedical Engineering. After his arrival at UW-Madison in 2005, Dr. Reeder founded a patient-oriented research program for the development and translation of advanced MRI methods into clinical practice. He leads the UW Liver Imaging Research Program, an active NIDDK-funded group developing and validating advanced MRI methods for improved diagnosis of abdominal diseases. The group is focused on validation of quantitative MRI biomarkers of diffuse liver disease, including methods to quantify abdominal adiposity and liver fat, liver iron overload, and non-invasive methods to evaluate the hemodynamics of the liver in patients with portal hypertension. Dr. Reeder has played a major mentoring role at UW-Madison as the Director of the Clinical MRI fellowship for the past 8 years and in his new role as Associate Director of the UW MD/PhD program. He has mentored a large number of medical students, residents, clinical fellows, graduate students, post-doctoral fellows and visiting professors in a wide variety of patient-oriented imaging projects. Most of these projects are interdisciplinary in focus and Dr. Reeder has built well-established collaborations with Pediatric Endocrinology, Emergency Medicine, Hepatology, Hematology, and Transplant Surgery, among others. Dr. Reeder is also the Medical Director of MRI at UW. His combined clinical and research leadership roles have enabled him to build a thriving mentoring environment for patient- oriented imaging research. Support from a K24 award would provide Dr. Reeder with the dedicated time needed to mentor clinicians performing patient-oriented research by freeing him from clinical and administrative responsibilities. Dr. Reeder will also continue his NIDDK funded R01 projects and participate in responsible conduct of research activities. He will also pursue a career development plan that includes additional training in liver disease and metabolic syndrome, as well as patient-centered outcomes research. Finally, he will perform a community-based patient-oriented research project examining the role of quantitative MRI biomarkers in the evolution of ectopic abdominal fat and insulin resistance during puberty in school-age girls. This interdisciplinary study will be performed as part of an ongoing mentorship-collaboration with a junior investigator in Pediatric Endocrinology. Given the outstanding environment at UW-Madison and this well- established mentoring relationship, this project is expected to lay the groundwork for future proposals including a K23 career development award for Dr. Reeder's mentee in Pediatric Endocrinology and will provide exciting new scientific insight into insulin resistance and ectopic abdominal fat deposition during puberty.

描述（由申请人提供）：这是K24中级研究员奖的新提交，以患者为导向研究，以支持Scott Reeder博士的指导，研究和职业发展活动。 Reeder博士是威斯康星大学麦迪逊分校的副教授，在医学，医学物理和生物医学工程系的放射学和跨任命任命。 Reeder博士于2005年到达UW-Madison后，建立了一项以患者为导向的研究计划，用于开发和翻译高级MRI方法为临床实践。他领导了UW肝脏成像研究计划，这是一个活跃的NIDDK资助的小组，开发和验证了高级MRI方法，以改善腹部疾病的诊断。该小组的重点是验证弥漫性肝病的定量MRI生物标志物，包括定量腹部肥胖和肝脂肪的方法，肝铁超负荷以及非侵入性方法评估病人的肝脏血液动力学，以评估肝脏高血压患者的肝动力学。 Reeder博士在过去的8年中曾在UW-Madison担任临床MRI奖学金主任，并担任UW MD/PHD计划的副总监。他指导了许多医学生，居民，临床研究员，研究生，博士后研究员以及各种以患者为导向的成像项目的客座教授。这些项目中的大多数都是跨学科的重点，而里德博士已经与儿科内分泌，急诊医学，肝病学，血液学和移植手术等建立了完善的合作。 Reeder博士还是UW MRI的医疗总监。他的临床和研究领导角色的结合使他能够建立一个蓬勃发展的指导环境，用于以患者为导向的成像研究。 K24奖的支持将为Reeder博士提供指导临床医生通过将其释放出临床和行政责任所需的专门时间。里德博士还将继续他的NIDDK资助的R01项目，并参与负责任的研究活动。他还将制定一项职业发展计划，其中包括肝病和代谢综合征的额外培训，以及以患者为中心的结果研究。最后，他将执行一个基于社区的以患者为基础的研究项目，研究定量MRI生物标志物在学龄前儿童青春期期间异位腹部脂肪和胰岛素耐药性进化中的作用。这项跨学科的研究将作为正在进行的指导 - 协助工作的一部分，并与小儿内分泌学的初级研究员一起进行。鉴于UW-Madison的杰出环境和这种良好的指导关系，该项目有望为未来的建议奠定基础，包括Reeder博士的儿科内分泌学指导者K23职业发展奖，并将为胰岛素提供令人兴奋的新科学见解。青春期期间的抗性和异位腹部脂肪沉积。