Prevalence of hantavirus infection in laboratory rats by indicator nude rats.

指示性裸鼠在实验室大鼠中汉坦病毒感染的患病率。

• 批准号: 08680908
• 负责人: DOHMAE Kayoko
• 金额: $ 1.47万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08680908/
• 关键词: HFRS; Hantavirus Infection; Zooosis; nude rat; cyclophosphamide; ヌード ラット; Hantavirus B-1株; ラット; 薬剤投与; 伝播様式

Recently we have reported a competent transmission of hantavirus to cagemates of T cell deficient Rowett nude rats which were shown to be highly susceptible to the hantavirus infection. Using this experimental system we have further analyzed the mechanism of hantavirus infection in laboratory rats. Infected wild type rats discharged infectious viruses for a long time soon after experimental intraperitoneal injection of virus. Viral transmission to indicator nude rats found to be occurred both via air-flow and by wood-tips soiled by the infected rats in natural breeding condition of laboratory animals. Thus, the infected rats discharge a large amount of infectious viruses which render them to be the origin of the prevalence of infection. However, the infection is very limited to the immunodeficient animals not to the wild type animals.

最近，我们报道了汉坦病毒向 T 细胞缺陷 Rowett 裸鼠的笼伴传播，这些裸鼠被证明对汉坦病毒感染高度敏感。利用该实验系统，我们进一步分析了实验室大鼠汉坦病毒感染的机制。感染的野生型大鼠在实验性腹腔注射病毒后不久就长时间排出传染性病毒。研究发现，在实验动物自然繁殖条件下，病毒向指示性裸​​鼠的传播是通过气流和受感染的裸鼠弄脏的木头传播的。因此，被感染的老鼠会释放出大量的传染性病毒，成为感染流行的根源。然而，感染非常限于免疫缺陷动物而不是野生型动物。