Stony Brook University Laboratory for Comparative Medicine to Support Pandemic Preparedness

石溪大学比较医学实验室支持流行病防范

基本信息

批准号：
10611662
负责人：
David G Thanassi
金额：
$ 293.31万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-16 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10611662
关键词：
2019-nCoV Adenoviruses Aerosols American Animal Model Animals Applied Research Area Basic Science Biological Products Biotechnology Bunyavirales COVID-19 COVID-19 therapeutics COVID-19 vaccine Containment Coronavirus Custom Dengue Virus Detection Disease Duct (organ) structure Faculty Family Family Picornaviridae Flaviviridae Francisella tularensis Funding Future Gases HIV Hantavirus High temperature of physical object Immune response Immunotherapy Individual Infection Influenza A virus Investigation Laboratories Measures Medicine Mycobacterium tuberculosis New York Pathogenesis Persons Phase Play Plumbing Population Powassan virus Preventive Process Publications Quantitative Reverse Transcriptase PCR RNA Viruses RNA analysis Recording of previous events Research Research Activity Research Personnel Resources Reverse Transcription Rickettsia Rodent Role Security Steam System Therapeutic Time Translational Research Treatment Efficacy Tuberculosis Tularemia Universities Viral Virulent Virus Water Work Zika Virus Zoonoses animal imaging anti-viral efficacy antimicrobial antiviral drug development biosafety level 3 facility combat comparative cost design emerging pathogen equipment acquisition exhaust experience flexibility fluorescence activated cell sorter device heat exchanger improved infectious disease model interest metropolitan microbial operation pandemic disease pandemic preparedness pathogen pathogenic bacteria pathogenic fungus pathogenic microbe pathogenic virus pre-clinical pre-clinical research programs spotted fever tool virology

2019-nCoV Adenoviruses Aerosols American Animal Model Animals Applied Research Area Basic Science Biological Products Biotechnology Bunyavirales COVID-19 COVID-19 therapeutics COVID-19 vaccine Containment Coronavirus Custom Dengue Virus Detection Disease Duct (organ) structure Faculty Family Family Picornaviridae Flaviviridae Francisella tularensis Funding Future Gases HIV Hantavirus High temperature of physical object Immune response Immunotherapy Individual Infection Influenza A virus Investigation Laboratories Measures Medicine Mycobacterium tuberculosis New York Pathogenesis Persons Phase Play Plumbing Population Powassan virus Preventive Process Publications Quantitative Reverse Transcriptase PCR RNA Viruses RNA analysis Recording of previous events Research Research Activity Research Personnel Resources Reverse Transcription Rickettsia Rodent Role Security Steam System Therapeutic Time Translational Research Treatment Efficacy Tuberculosis Tularemia Universities Viral Virulent Virus Water Work Zika Virus Zoonoses animal imaging anti-viral efficacy antimicrobial antiviral drug development biosafety level 3 facility combat comparative cost design emerging pathogen equipment acquisition exhaust experience flexibility fluorescence activated cell sorter device heat exchanger improved infectious disease model interest metropolitan microbial operation pandemic disease pandemic preparedness pathogen pathogenic bacteria pathogenic fungus pathogenic microbe pathogenic virus pre-clinical pre-clinical research programs spotted fever tool virology

展开

项目摘要

PROJECT SUMMARY/ABSTRACT The Laboratory for Comparative Medicine (LCM) at Stony Brook University is a recently constructed, state-of- the-art animal biosafety level 3 (ABSL3) facility. The LCM is actively engaged in basic, translational, and preclinical research on SARS-CoV-2, the viral agent of the current COVID-19 worldwide pandemic. Research in the LCM serves multiple individual investigators and groups, both within and outside of Stony Brook University, and includes commercial as well as academic interests. Stony Brook has a long history of excellence in microbial pathogenesis research, including studies on pandemic potential viruses of concern in the families Coronaviridae (SARS-CoV-2), Bunyavirales (Hantaviruses), Flaviviridae (Dengue, Zika, and Powassan viruses), and Picornaviridae (Poliovirus). Stony Brook virologists are also conducting ongoing studies in Human Immunodeficiency Virus and Influenza A Virus. Our research over the past five years has covered three different RNA virus families relevant under the American Pandemic Preparedness/pandemic preparedness effort, and our cumulative experience covers four of the viral families of concern. In addition to viruses of concern, active research at Stony Brook and in the LCM includes work on the highly virulent bacterial agents Rickettsia spp. of the spotted fever group, Francisella tularensis, a Select Agent and cause of the zoonotic disease tularemia, and Mycobacterium tuberculosis, causative agent of tuberculosis. To improve facility operations and enhance ongoing and future research in the LCM, we are requesting four upgrades to the LCM: 1) Replacement of the high temperature hot water unfired steam boilers and conversion of the high temperature and hot water systems; 2) Purchase and installation of a washer for animal cages and racks; 3) Purchase and installation of a fluorescence-activated cell sorter and custom biosafety enclosure; and 4) Acquisition of a real-time, quantitative reverse-transcription PCR machine. The requested upgrades will support and improve pandemic preparedness-relevant research in the LCM, advance studies on highly virulent and emerging pathogens, and provide enhanced resources not only to Stony Brook researchers, but also to State and regional efforts to combat current and future pandemic threats. The requested improvements will support the development of antiviral programs and antimicrobial preventive and therapeutic measures.

项目摘要/摘要 Stony Brook University的比较医学实验室（LCM）是最近建造的，最新的艺术动物生物安全3级（ABSL3）设施。 LCM积极从事基本，翻译和临床前研究SARS-COV-2，这是当前COVID-19的病毒药物，全球大流行。研究在LCM中，在Stony Brook的内外服务了多个个人调查员和团体大学，包括商业和学术兴趣。斯托尼·布鲁克（Stony Brook）有着悠久的历史微生物发病机理研究的卓越性，包括有关大流行潜在病毒关注的研究 Coronaviridae（SARS-COV-2），Bunyavirales（Hantaviruess），Flaviviridae（登革热，Zika和 Powassan病毒）和Picornaviridae（脊髓灰质炎病毒）。 Stony Brook病毒学家也正在进行持续人类免疫缺陷病毒和流感病毒的研究。我们过去五年来我们的研究涵盖了美国大流行准备/大流行中相关的三种不同的RNA病毒家族准备工作和我们的累积经验涵盖了四个关注的病毒家庭。此外关注的病毒，Stony Brook和LCM中的积极研究包括在高度毒气上的工作细菌剂立克属。斑点发烧组，弗朗西斯菌（Francisella tularensis）人畜共患病tularemia和结核分枝杆菌，结核病的病因。改进设施运营并增强LCM中正在进行和未来的研究，我们要求四次升级到 LCM：1）更换高温热水未燃蒸汽锅炉并转换高温度和热水系统； 2）购买和安装用于动物笼子和架子的洗衣机； 3）购买和安装荧光激活的细胞分选仪和定制的生物安全外壳；和4）获取实时的定量反向转录PCR机器。请求的升级将在LCM中支持并改善与大流行的相关研究，对高毒性进行预先研究以及新兴的病原体，不仅为Stony Brook的研究人员提供增强的资源，还为国家和区域努力应对当前和未来的大流行威胁。请求的改进将支持开发抗病毒计划以及抗菌预防和治疗措施。