Evaluation of the pathophysiological significance of peripheral clocks and the development of methods of controlling them

外周时钟病理生理学意义的评估及其控制方法的开发

• 批准号: 21790880
• 负责人: ANDO Hitoshi
• 金额: $ 2.75万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790880/
• 关键词: メタボリックシンドローム; 体内時計; 時計遺伝子; 2型糖尿病

To elucidate the physiological significance and controlling mechanism of peripheral clocks, the biological clocks in obese diabetic ob/ob mice were studied. The impairment of circadian clocks in ob/ob mice was (1) found in the peripheral tissues, but not in the suprachiasmatic nucleus (central clock), (2) detectable before the development of metabolic abnormalities, and (3) improved by short-term treatment with leptin. These results suggest that the impairment of peripheral clocks is not a result of metabolic derangement and that leptin signaling is important for maintaining the peripheral clock functions.

为了阐明外周生物钟的生理意义和控制机制，对肥胖糖尿病ob/ob小鼠的生物钟进行了研究。 ob/ob 小鼠的生物钟受损（1）在外周组织中发现，但在视交叉上核（中央时钟）中未发现，（2）在代谢异常发生之前可检测到，（3）通过短期治疗得到改善。瘦素的长期治疗。这些结果表明，外周生物钟受损并不是代谢紊乱的结果，瘦素信号传导对于维持外周生物钟功能很重要。

项目成果

Impairment of peripheral circadian clocks precedes metabolic abnormalities in ob/ob mice

ob/ob 小鼠的外周生物钟受损先于代谢异常

• 发表时间: 2011
• 影响因子: 4.8
• 作者: Hitoshi Ando

健常人女性における末梢血時計遺伝子発現におよぼす年齢およびシフトワークの影響

年龄和轮班工作对健康女性外周血钟基因表达的影响

• 发表时间: 2009
• 作者: 安藤仁

Influence of age on clock gene expression in peripheral blood cells of healthy women.

年龄对健康女性外周血细胞时钟基因表达的影响。

• DOI: 10.1093/gerona/glp160
• 发表时间: 2024-09-13
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: H. Ando;K. Ushijima;M. Kumazaki;T. Takamura;Noritsugu Yokota;Tetsuo Saitô;S. Irie;S. Kaneko;A. Fujimura
• 通讯作者: A. Fujimura

糖尿病の時間治療

糖尿病时间疗法

• 发表时间: 2010
• 作者: 安藤仁

Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men.

健康男性代谢参数和乙醇消耗与时钟基因信使 RNA 表达的关联。

• 发表时间: 2010
• 作者: Hitoshi Ando