Identification of Lung Cancer Stem Cell Markers

肺癌干细胞标志物的鉴定

• 批准号: 23659664
• 负责人: SUZUKI Motoshi
• 金额: $ 2.33万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659664/
• 关键词: 癌幹細胞; マーカー; 肺癌; がん幹細胞; 分子標的

By using clinical specimens, we performed IHC analysis for the putative cancer-initiating cell markers. Among the markers, we found CD166 may be the mostuseful one. To identify novel lung cancer-initiating cell markers, we analyzed an open database, screened genes that were highly expressed in CD166-positive cells, measured expression levels of such genes in the clinical specimens, and performed shRNA-induced knocking-down experiments. We identified that a gene could be a novel lung cancer-initiating cell marker, as well as a future target for the cancer treatment.

通过使用临床标本，我们对假定的癌症起始细胞标记物进行了 IHC 分析。在这些标记中，我们发现 CD166 可能是最有用的一种。为了鉴定新型肺癌起始细胞标志物，我们分析了开放数据库，筛选了CD166阳性细胞中高表达的基因，测量了临床标本中此类基因的表达水平，并进行了shRNA诱导的敲低实验。我们发现一个基因可能是一种新型肺癌起始细胞标记，也是未来癌症治疗的目标。

项目成果

Hybrid liposomes affect cellular lipid constituents and caveolae structures

混合脂质体影响细胞脂质成分和细胞膜穴结构

• DOI: 10.1016/j.bmcl.2011.12.093
• 发表时间: 2012
• 期刊: Bioorg Med Chem Lett
• 影响因子: 2.7
• 作者: 吉川 豊;藤本重行;安井裕之;Cao K
• 通讯作者: Cao K

A pivotal role of CerS6 on the ceramide metabolic pathways and tumor metastasis in lung cancer

CerS6对肺癌神经酰胺代谢途径和肿瘤转移的关键作用

• 发表时间: 2012
• 作者: Motoshi Suzuki;Ke Cao;Kouji Tanaka;Seiichi Kato;Chinatsu Arima;Yasuyuki Hosono;Kiyoshi Yanagisawa;Keiko Tamiya-Koizumi;Takashi Murate;Mamoru Kyogashima and Takashi Takahashi
• 通讯作者: Mamoru Kyogashima and Takashi Takahashi

MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis

• DOI: 10.1038/emboj.2011.416
• 发表时间: 2012-01-18
• 期刊: EMBO JOURNAL
• 影响因子: 11.4
• 作者: Hosono, Yasuyuki;Yamaguchi, Tomoya;Takahashi, Takashi
• 通讯作者: Takahashi, Takashi

MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility

• DOI: 10.1016/j.bbrc.2012.10.036
• 发表时间: 2012-11-09
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: HosonoA, Yasuyuki;Usukura, Jiro;Takahashi, Takashi
• 通讯作者: Takahashi, Takashi

a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motilityand metastasis

TTF-1 的转录靶标，抑制 ROCK1，并降低细胞运动和转移

• 发表时间: 2012
• 期刊: EMBO J
• 影响因子: 11.4
• 作者: Hosono Y;Yamaguchi T;Mizutani E;Yanagisawa K;Arima C;Tomida S;Shimada Y;Hiraoka M;Kato S;Yokoi K;Suzuki M;Takahashi T. MYBPH
• 通讯作者: Takahashi T. MYBPH