The role of stress proteins in gastrointestinal and respiratory diseases

应激蛋白在胃肠道和呼吸系统疾病中的作用

• 批准号: 22790072
• 负责人: TANAKA Kenichiro
• 金额: $ 2.5万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790072/
• 关键词: 消化管; 呼吸器疾患; ストレス

Idiopathic pulmonary fibrosis(IPF) is thought to involve inflammatory infiltration of leukocytes, lung injury induced by reactive oxygen species(ROS), in particular superoxide anion, and fibrosis(collagen deposition). Intravenous administration of PC-SOD suppressed the bleomycin-induced increase in the number of leukocytes in bronchoalveolar lavage fluid. Bleomycin-induced collagen deposition and increased hydroxyproline levels in the lung were also suppressed in animals treated with PC-SOD, suggesting that PC-SOD suppresses bleomycin-induced pulmonary fibrosis.

特发性肺纤维化（IPF）被认为涉及白细胞的炎症性浸润，由活性氧（ROS）诱导的肺损伤，特别是超氧化物阴离子和纤维化（胶原蛋白沉积）。 PC-SOD的静脉内给药抑制了博来霉素诱导的支气管肺泡灌洗液中白细胞数量的增加。在用PC-SOD处理的动物中，还抑制了肺中博来霉素诱导的胶原蛋白沉积，并抑制了肺中的羟基水平，这表明PC-SOD抑制了博来霉素诱导的肺纤维化。

项目成果

Therapeutic Effect of Lecithinized Superoxide Dismutase on Pulmonary Emphysema

• DOI: 10.1124/jpet.111.179051
• 发表时间: 2011-09-01
• 期刊: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
• 影响因子: 3.5
• 作者: Tanaka, Ken-Ichiro;Tanaka, Yuta;Mizushima, Tohru
• 通讯作者: Mizushima, Tohru

Therapeutic effect of lecithinized superoxide dismutase (PC-SOD) on bleomycin-induced pulmonary fibrosis.

卵磷脂化超氧化物歧化酶（PC-SOD）对博来霉素诱导的肺纤维化的治疗作用。

• 发表时间: 2010
• 期刊: Am J Physiol Lung Cell Mol Physiol.
• 作者: Tanaka KI.;Ishihara T.;Azuma A.;Kudoh S.;Ebina M.;Nukiwa T.;Sugiyama Y.;Tasaka Y.;Namba T.;Ishihara T.;Sato K.;Mizushima Y.;Mizushima T.
• 通讯作者: Mizushima T.

Stimulation of gastric ulcer healing by heat shock protein 70

• DOI: 10.1016/j.bcp.2011.06.030
• 发表时间: 2011-10-01
• 期刊: BIOCHEMICAL PHARMACOLOGY
• 影响因子: 5.8
• 作者: Ishihara, Tomoaki;Suemasu, Shintaro;Mizushima, Tohru
• 通讯作者: Mizushima, Tohru

Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice

• DOI: 10.1016/j.bcp.2010.05.025
• 发表时间: 2010-09-15
• 期刊: BIOCHEMICAL PHARMACOLOGY
• 影响因子: 5.8
• 作者: Tanaka, Ken-Ichiro;Tanaka, Yuta;Mizushima, Tohru
• 通讯作者: Mizushima, Tohru

Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70.

通过表达热休克蛋白70来预防紫外线B辐射引起的表皮损伤。

• 发表时间: 2010
• 期刊: J Biol Chem 285
• 作者: Matsuda M;Hoshino T;Yamashita Y;Tanaka KI;Maji D;Sato K;Adachi H;Sobue G;Ihn H;Funasaka Y;Mizushima T.
• 通讯作者: Mizushima T.