Analysis of estrogen signaling specific and/or common to brainfunction and cancer, and its clinical relevance

分析脑功能和癌症特异性和/或常见的雌激素信号传导及其临床相关性

• 批准号: 22591016
• 负责人: IKEDA Kazuhiro
• 金额: $ 2.75万
• 依托单位: Saitama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591016/
• 关键词: エストロゲン; 脳; がん; 転写; 遺伝子; 乳がん

Estrogen plays important roles in brain function and breast cancer. In this study, I aimed to explore the novel estrogen-responsive genes in brain and cancer tissues for identifying specific and/or common estrogen signaling pathway between these tissues. In addition to estrogen-responsive genes that we have previously reported, clinical relevance of these estrogen-responsive genes is also explored. We identified novelestrogen-responsive genes specific in hippocampus, hypothalamus and brain stem. These novel estrogen-responsive genes are known to be associated with breast cancer. We also demonstrated that the expression of transcription factors, FOXA1 and FOXP1 is induced by estrogen in breast cancer cells and immunoreactivities of FOXA1 and FOXP1 are positively correlated with good prognosis of breast cancer patients with tamoxifen treatment. These findings would uncover novel role of estrogen signaling in brain function and cancers.

雌激素在脑功能和乳腺癌中起重要作用。在这项研究中，我旨在探索脑和癌组织中新型的雌激素反应基因，以识别这些组织之间的特定和/或常见的雌激素信号传导途径。除了我们先前报道的雌激素反应基因外，还探讨了这些雌激素反应性基因的临床相关性。我们确定了海马，下丘脑和脑干中特有的新型雌激素响应基因。这些新型的雌激素反应基因已知与乳腺癌有关。我们还证明了转录因子，FOXA1和FOXP1的表达是由雌激素在乳腺癌细胞中诱导的，FOXA1和FOXP1的免疫反应性与他莫昔芬治疗的乳腺癌患者的良好预后呈正相关。这些发现将发现雌激素信号传导在脑功能和癌症中的新作用。

项目成果

子宮内膜癌におけるFOXA1の発現は予後良好因子に関連する

子宫内膜癌中 FOXA1 的表达与有利的预后因素相关

• 发表时间: 2011
• 作者: Saito TI;Li HW;Sykes M.;阿部弥生
• 通讯作者: 阿部弥生

Integrative analysis of phosphoproteome and transcriptome dynamics defines drug-resistance properties of breast cancer

磷酸蛋白质组和转录组动力学的综合分析定义了乳腺癌的耐药特性

• 发表时间: 2010
• 作者: 高橋 裕;尾山大明
• 通讯作者: 尾山大明

Estrogen-related receptor γ modulates cell proliferation and estrogen signaling in breast cancer

• DOI: 10.1016/j.jsbmb.2010.09.002
• 发表时间: 2011-01-01
• 期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
• 影响因子: 4.1
• 作者: Ijichi, Nobuhiro;Shigekawa, Takashi;Inoue, Satoshi
• 通讯作者: Inoue, Satoshi

TACC2 Is an Androgen-Responsive Cell Cycle Regulator Promoting Androgen-Mediated and Castration-Resistant Growth of Prostate Cancer

• DOI: 10.1210/me.2011-1242
• 发表时间: 2012-05-01
• 期刊: MOLECULAR ENDOCRINOLOGY
• 作者: Takayama, Ken-ichi;Horie-Inoue, Kuniko;Inoue, Satoshi
• 通讯作者: Inoue, Satoshi

MicroRNA profiling of tamoxifen-sensitive and -resistant breast cancer MCF-7 cells analyzed by deep sequencing

通过深度测序分析他莫昔芬敏感和耐药乳腺癌 MCF-7 细胞的 MicroRNA 谱

• 发表时间: 2012
• 作者: Ikeda K;Horie-Inoue K;Mano H;Inoue S
• 通讯作者: Inoue S