Evaluation of the effect of co-existing dissolved organic matters on the bioavailability of hydrophobic organic compounds

共存溶解有机物对疏水性有机化合物生物利用度的影响评价

• 批准号: 22710034
• 负责人: IKEDA Kazuhiro
• 金额: $ 2.58万
• 依托单位: Center for Environmental Science in Saitama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22710034/
• 关键词: 生物利用性; 溶存有機物質; 疎水性有機汚染物質; 医薬品; 多環式芳香族炭化水素; モデル細胞膜; 収着; 毒性; バイオアッセイ; 生物利用性; 溶存有機物質; 疎水性有機汚染物質; 医薬品; 多環式芳香族炭化水素; モデル細胞膜; 収着; 毒性; バイオアッセイ

The effect of co-existing dissolved organic matters on the bioavailability of hydrophobic organic compounds was evaluated using artificial cell membrane as surrogate of aquatic organisms in order to figure out toxicity reduction with dissolved organic matters. The bioavailability of pyrene, 1-hydoxypyrene, 1-aminopyrene and fluoxetine were decreased with their sorption to dissolved organic matters. The largest reduction was 1.1% in Arakawa river and 5.2% in sewage treatment plant effluent, respectively. The sorption coefficients of pyrene to them were comparable to colored river in the United States.

使用人造细胞膜作为水生生物的替代物，评估了共存有机物的共存有机物对疏水有机化合物的生物利用度的影响，以找出溶解有机物的毒性降低。 pyr素，1-羟基氧基，1-氨基吡啶和氟西汀的生物利用度随着它们的吸附至溶解有机物而降低。 Arakawa河的最大减少量为1.1％，污水处理厂分别为5.2％。吡啶对它们的吸附系数与美国的有色河流相当。