Alteration of fucosylation and biomarker development in lung cancer

肺癌中岩藻糖基化的改变和生物标志物的发展

• 批准号: 22501029
• 负责人: AKITA Hirotoshi
• 金额: $ 2.75万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22501029/
• 关键词: バイオマーカー; 肺癌; 糖鎖; 糖転移酵素〓1-6fucosyltransferase; 非小細胞肺癌; 糖転移酵素; alfa 1-6フコース転移酵素; alfa1,6-フコース転移酵素; α1,6-フコース転移酵素

High 〓1-6 fucosyltransferase (〓1-6 FucT) expression is more frequently found in adenocarcinomas than squamous cell carcinomas, and is correlated with advanced pN status in adenocarcinomas. High 〓1,6-FT expression is associated with an unfavorable clinical outcome in potentially curatively resected and pStage I adenocarcinomas. These findings suggest that 〓1,6-FT and its core-fucosylated products could be promisingbiomarkers and therapeutic targets for NSCLCs, especially for adenocarcinomas.

高1-6的1-6岩藻糖基转移酶（〓1-6FUCT）表达在腺癌中比鳞状细胞癌更具基础，在腺癌中，高级PN状态是腺癌的。 Pstage I腺癌。

项目成果

Decreased expression of GMD in non-small cell lung cancers (NSCLCs)

非小细胞肺癌 (NSCLC) 中 GMD 表达降低

• 发表时间: 2011
• 作者: Honma R;et al.
• 通讯作者: et al.

Decreased expression of GMDand GDP-fucose transporter is associated with squamous histology in NSCLCs.

GMD 和 GDP-岩藻糖转运蛋白表达的降低与 NSCLC 中的鳞状组织学相关。

• 发表时间: 2011
• 作者: Honma R;Dosaka-Akita H;Kinoshita I
• 通讯作者: Kinoshita I

Decreased expression of GMD in non-small cell lung cancers (NSCLCs).

非小细胞肺癌 (NSCLC) 中 GMD 表达降低。

• 发表时间: 2011
• 作者: Honma R;Dosaka-Akita H;Kinoshita I
• 通讯作者: Kinoshita I