Investigation into the pathology of ocular ischemic disorders by controlling the the blood cell-endothelial cell interactions and hypoxia imaging

通过控制血细胞-内皮细胞相互作用和缺氧成像研究眼部缺血性疾病的病理学

• 批准号: 21390466
• 负责人: MIYAMOTO Kazuaki
• 金额: $ 11.32万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390466/
• 关键词: 眼虚血性疾患; 網膜循環; 網膜静脈閉塞症; 黄斑浮腫; IS/OSライン; 漿液性網膜剥離; ミュラー細胞円錐; 黄斑部局所網膜電図; 黄斑部機能; PhNR; 白血球-血管内皮相互反応; 高解像度光干渉断層計; 網膜剥離; 抗血管内皮増殖因子(VEGF)抗体; 視力; 3次元光干渉断層計; 網膜感度; 網膜視細胞内節外節結合部(IS; OS)

We investigated the pathology of retinal vein occlusion(RVO) that is a representative disease of retinal circulatory disturbances, one of ocular ischemic disorders. The followings were elucidated : 1) in eyes with macular edema associated with RVO, when the junction line between inner and outer segments of the photoreceptors was detected beneath the fovea, they would be expected to have good vision after resolution of the macular edema, 2) the foveal architecture, especially that of the Muller cell cone, plays an important role in the formation of serous retinal detachment associated with RVO, and 3) focal macular electroretinography is useful as a functional examination within the macular area affected by RVO, etc.

我们研究了视网膜静脉闭塞（RVO）的病理学，该病理是视网膜循环障碍的代表性疾病，是眼部缺血性疾病之一。阐明了以下内容：1）在与RVO相关的黄斑水肿相关的眼睛中，当检测到光感受器的内部和外部段之间的连接线在凹内凹下方，预计它们在分辨出黄斑水肿后具有良好的视力，2 ）中央凹建筑，尤其是Muller细胞锥体的结构，在与RVO相关的浆液性视网膜脱离的形成中起着重要作用，3）局灶性黄斑电子图可作为受RVO影响的黄斑区域内的功能检查。

项目成果

Visual Acuity Following Intravitreal Bevacizumab for Macular Edema Associated with Retinal Vein Occlusion

• DOI: 10.1007/s10384-010-0878-x
• 发表时间: 2010-11-01
• 期刊: JAPANESE JOURNAL OF OPHTHALMOLOGY
• 影响因子: 2.4
• 作者: Ota, Masafumi;Tsujikawa, Akitaka;Yoshimura, Nagahisa
• 通讯作者: Yoshimura, Nagahisa

Etiology of carotid cavernous fistula in Japanese

日本颈动脉海绵窦瘘的病因学

• 发表时间: 2009
• 期刊: Jpn J Ophthalmol
• 影响因子: 2.4
• 作者: Oishi A;Miyamoto K;Yoshimura N.
• 通讯作者: Yoshimura N.

網膜静脈閉塞症における黄斑局所網膜電図

视网膜静脉阻塞黄斑局部视网膜电图

• 发表时间: 2010
• 作者: 荻野顕;中村元;辻川明孝;宮本和明;村上智明;坂本篤;太田将文;吉村長久
• 通讯作者: 吉村長久

網膜静脈閉塞症における硬性白斑のSpectral is OCT所見

光谱为视网膜静脉阻塞硬性白癜风的OCT表现

• 发表时间: 2010
• 作者: 荻野顕;村上智明;辻川明孝;宮本和明;坂本篤;太田将文;村岡勇貴;倉重由美子;吉村長久
• 通讯作者: 吉村長久

STERILE ENDOPHTHALMITIS AFTER INTRAVITREAL INJECTION OF BEVACIZUMAB OBTAINED FROM A SINGLE BATCH

• DOI: 10.1097/iae.0b013e3181bd2d51
• 发表时间: 2010-03-01
• 期刊: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
• 影响因子: 3.3
• 作者: Yamashiro, Kenji;Tsujikawa, Akitaka;Yoshimura, Nagahisa
• 通讯作者: Yoshimura, Nagahisa