The roles of sex hormone and gender difference for spinal cord protection in spinal cord ischemia

性激素及性别差异在脊髓缺血中的脊髓保护作用

• 批准号: 21591970
• 负责人: IIDA Hiroki
• 金额: $ 2.83万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591970/
• 关键词: 性ホルモン; エストロジェン; リモートプレコンディショニング; 脊髄虚血; 性差; 性ステロイド; 対麻痺; 脊髄保護

We evaluated the tissue oxygen partial pressure of spinal cord(PsptO2) following aortic cross-clamping and-unclamping, and then clarified the mechanism of improvement in the PsptO2 following spinal ischemia observed with remote ischemic preconditioning(RIPC) or intravenous estrogen in rabbits. In isoflurane anesthetized rabbits(n=36), we prepared for measurement of PsptO2 following aortic cross-clamping using tissue PO2 monitoring. In the first set of experiment, we allocated 18 animals into 3 groups,(a) control group ; n=6,(b) RIPC group ; n=6,(c) glibenclamide pretreatment(0. 3mg/kg) group ; n=6. In the second set of experiment, we also allocated 18 animals into 3 groups,(d) control group ; n=6,(e) estrogen(17ss estradiol : 20μg) group ; n=6,(f) fulvestrant pretreatment(1mg/kg) group ; n=6. RIPC improved deterioration of the values in PsptO2 at 20 min after aortic cross-clamping and 0, 2, 5 min after aortic unclamp. The improvement was diminished by pretreatment of glibenclamide. Administration of 17s estradiol improved deterioration of the values in PsptO2 at 20 min after aortic cross-clamping and 0, 2, 5 min after aortic unclamp. The improvement was diminished by pretreatment of fulvestrant.In conclusion, after aortic cross-clamping, the RIPC performed improves the deterioration in PsptO2 through the KATP channel activation and 17ss estradiol improves the deterioration in PsptO2 through the estrogen receptor activation.

我们评估了SPTO2的组织氧气压力）在主动脉交叉钳位和毫无障碍的障碍中，在脊柱缺血后观察到了脊柱缺血后远程静脉内雌激素的脊髓症。 po2监测IRST的实验，我们将18个动物分配给3组，（a）对照组；（b）RIPC组； 6。在第二组实验中，（d）对照组; n = 6，（e）雌激素（17SS雌二醇：20μg）n = 6，（F） ; n = 6。在主动脉交叉夹后20分钟，主动脉脱落后的0、2、5分钟。主动脉脱落后的最小值。

项目成果

Preconditioning with estrogen lmproves the deterioration of the tissue oxygen partial pressure of spinal cord after Aortic Cross-Clamping

雌激素预处理改善主动脉阻断术后脊髓组织氧分压恶化

• 发表时间: 2010
• 作者: Takenaka M;Iida M;Iida H.
• 通讯作者: Iida H.

周術期禁煙

围手术期戒烟

• 发表时间: 2011
• 期刊: 臨床麻酔
• 作者: 飯田宏樹;加藤真有美
• 通讯作者: 加藤真有美

プロタミン投与後にアナフィラキシー様ショックを起こした症例

服用鱼精蛋白后过敏性休克一例

• 发表时间: 2012
• 期刊: 臨床麻酔
• 作者: 山田忠則;鬼頭和裕;太田宗一郎;大畠博人;飯田宏樹
• 通讯作者: 飯田宏樹

Midazolam suppresses interleukin1 ss-induced interleukin-6 release from rat glial cells

咪达唑仑抑制大鼠神经胶质细胞中白细胞介素 1 SS 诱导的白细胞介素 6 释放

• 发表时间: 2011
• 期刊: J Neuroinflammation
• 作者: Tanabe K;Kozawa O;Iida H.
• 通讯作者: Iida H.

術中に用いるオピオイドの種類によるベクロニウム使用料の比較

不同手术期间使用的阿片类药物类型的维库溴铵使用费用比较

• 发表时间: 2012
• 期刊: 麻酔
• 作者: 長瀬清;飯田宏樹
• 通讯作者: 飯田宏樹