Studies on the effects of alpha-agonist and Ca antagonist for maintaining cerebral blood flow after cardiopulmonary resuscitation.

α受体激动剂和Ca拮抗剂对心肺复苏后脑血流维持作用的研究

基本信息

批准号：
06671513
负责人：
IIDA Hiroki
金额：
$ 0.77万
依托单位：
Gifu University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671513/
关键词：
resuscitation cerebral perfusion pial vessel brain protection alpha-2 agonist α2作動薬 α2作用薬

项目摘要

Brain protection during and after CPR (cardiopulmonary resuscitation) is one of the critical problems. Maintaining of the cerebral perfusion might be important to protect the brain damage. Recent reports have demonstrated that dexmedetomidine improves neurologic outcomes from ischemia. The aim of this study was to clarify whether the administration of dexmedetomidine during CPR resulted in improved cerebral perfusion.(1) To determine the direct effects of dexmedetomidine on normal cerebral vessels.Using cranial window method, we measured the diameters of pial arterioles and venules following the topical administration of dexmedetomidine. Dexmedetomidine constricted both pial arterioles and venules in dose-dependent manner.(2) To determine the effect of dexmedetomidine for maintaining the cerebral perfusion.Using cranial window method, we measured the diameter of pial arterioles and venules after CPR with or without dexmedetomidine. The addition of dexmedetomidine did not demonstrated the apparent improvement of cerebral perfusion fro point of the changes of diameters of cerebral bessels. However, dexmedetomidine reduced the incidence of serious dysrhythmia after CPR.In conclusion, we could not clarify the conclusive evidence that dexmedetomidine could improve cerebral perfusion after CPR.However, the stability of hemodynamics by the addition of dexmedetomidine might contribute to improved outcome after CPR.

CPR（心肺复苏）期间和之后的大脑保护是关键问题之一。维持脑灌注对于保护脑损伤可能很重要。最近的报告表明，右美托咪定可改善缺血引起的神经系统结果。本研究的目的是阐明心肺复苏期间给予右美托咪定是否可以改善脑灌注。（1）确定右美托咪定对正常脑血管的直接影响。采用颅窗法测量软脑膜小动脉和小静脉的直径局部给予右美托咪定后。右美托咪定以剂量依赖性方式收缩软脑膜小动脉和小静脉。(2)为了确定右美托咪定维持脑灌注的效果。采用颅窗法测量使用或不使用右美托咪定进行心肺复苏后软脑膜小动脉和小静脉的直径。从脑贝塞尔直径的变化来看，添加右美托咪定并没有显示出脑灌注的明显改善。然而，右美托咪定降低了CPR后严重心律失常的发生率。总之，我们无法澄清右美托咪定可以改善CPR后脑灌注的确凿证据。然而，添加右美托咪定血流动力学的稳定性可能有助于改善CPR后的结局。