Studies on the effects of alpha-agonist and Ca antagonist for maintaining cerebral blood flow after cardiopulmonary resuscitation.

α受体激动剂和Ca拮抗剂对心肺复苏后脑血流维持作用的研究

基本信息

批准号：
06671513
负责人：
IIDA Hiroki
金额：
$ 0.77万
依托单位：
Gifu University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671513/
关键词：
resuscitation cerebral perfusion pial vessel brain protection alpha-2 agonist α2作動薬 α2作用薬

项目摘要

Brain protection during and after CPR (cardiopulmonary resuscitation) is one of the critical problems. Maintaining of the cerebral perfusion might be important to protect the brain damage. Recent reports have demonstrated that dexmedetomidine improves neurologic outcomes from ischemia. The aim of this study was to clarify whether the administration of dexmedetomidine during CPR resulted in improved cerebral perfusion.(1) To determine the direct effects of dexmedetomidine on normal cerebral vessels.Using cranial window method, we measured the diameters of pial arterioles and venules following the topical administration of dexmedetomidine. Dexmedetomidine constricted both pial arterioles and venules in dose-dependent manner.(2) To determine the effect of dexmedetomidine for maintaining the cerebral perfusion.Using cranial window method, we measured the diameter of pial arterioles and venules after CPR with or without dexmedetomidine. The addition of dexmedetomidine did not demonstrated the apparent improvement of cerebral perfusion fro point of the changes of diameters of cerebral bessels. However, dexmedetomidine reduced the incidence of serious dysrhythmia after CPR.In conclusion, we could not clarify the conclusive evidence that dexmedetomidine could improve cerebral perfusion after CPR.However, the stability of hemodynamics by the addition of dexmedetomidine might contribute to improved outcome after CPR.

CPR期间和之后的脑部保护（心肺复苏）是关键问题之一。保持脑灌注可能对于保护脑损伤可能很重要。最近的报道表明，右美托胺可改善缺血的神经系统结局。这项研究的目的是澄清CPR期间的右美托胺的给药是否改善了脑灌注。（1）确定右美托胺对正常脑血管的直接影响。使用颅窗方法，我们测量了皮亚尔动脉和venules的直径在piale虫和venules的直径后，在甲状腺素和venules的局部疗法疗养疗程。右美托汀以剂量依赖性的方式收缩了脊椎小动脉和静脉。（2）确定右美托胺对维持脑灌注的作用。使用颅窗方法，我们测量了与或不无右丙氨酸的CPR的幼崽小动脉和静脉的直径。右美依胺的添加并未证明大脑贝塞尔直径变化的脑灌注的明显改善。然而，右美托汀在CPR.CPR后降低了严重的心律失常的发生率，我们无法澄清得出的证据，即右美托咪定可以改善CPR之后的脑灌注。但是，CPR后，通过添加右旋乙他的右旋乙胺的稳定性可能会改善CPR后CPR后的结果。