Study for mechanism of cell cycle regulation by ubiquitin ligase in triple-negative breast cancer

泛素连接酶调控三阴性乳腺癌细胞周期的机制研究

• 批准号: 21591671
• 负责人: YAMAMOTO Yutaka
• 金额: $ 2.91万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591671/
• 关键词: 乳腺外科学; ユビキチンリガーゼ; Fbw7; skp2; 乳癌; トリプルネガティブ乳癌; Skp2; 予後因子; 細胞周期

We studied clinical significance of ubiquitin ligase(skp2 and Fbw7) in breast cancer and potential of ubiquitin ligase targeting-therapy for breast cancer. Fbw7 downregulation and skp2 overexpression were significantly correlated with aggressive phenotype in breast cancer. Fbw7 knockdown led to suppression of proliferation in breast cancer cells.

我们研究了泛素连接酶（SKP2和FBW7）在乳腺癌中的临床意义以及泛素连接酶靶向乳腺癌的潜力。 FBW7下调和SKP2过表达与乳腺癌中的侵袭性表型显着相关。 FBW7敲低导致抑制乳腺癌细胞增殖。

项目成果

Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients

• DOI: 10.1111/j.1349-7006.2010.01801.x
• 发表时间: 2011-02-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Ibusuki, Mutsuko;Yamamoto, Yutaka;Iwase, Hirotaka
• 通讯作者: Iwase, Hirotaka

Clinicopathological features and treatment strategy for triple-negative breast cancer

• DOI: 10.1007/s10147-010-0106-1
• 发表时间: 2010-08-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Yamamoto, Yutaka;Iwase, Hirotaka
• 通讯作者: Iwase, Hirotaka

Clinical significance of basal-like subtype in triple-negative breast cancer

• DOI: 10.1007/s12282-009-0150-8
• 发表时间: 2009-10-01
• 期刊: BREAST CANCER
• 影响因子: 4
• 作者: Yamamoto, Yutaka;Ibusuki, Mutsuko;Iwase, Hirotaka
• 通讯作者: Iwase, Hirotaka