Physiological function of Na pumpα3 subunit gene and involvement in pathophysiology of dystonia parkinsonism.

Na泵α3亚基基因的生理功能及其参与肌张力障碍帕金森病的病理生理学。

• 批准号: 21590239
• 负责人: KAWAKAMI Kiyoshi
• 金额: $ 3万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590239/
• 关键词: ナトリウムポンプα3サブユニット; 小脳; プルキンエ細胞; シナプス伝達; 電気生理学; 抑制性ニューロン; カルシウム; 発現部位; c-Fos; 運動量; 行動テスト; 小脳神経伝達; 神経伝達物質

Dystonia is characterized by excessive involuntary and prolonged simultaneous contractions of both agonist and antagonist muscles. One hereditary form of dystonia, DYT12, is caused by loss of function mutations of the gene forα3 isoform of Na pump(ATP1A3). To provide insight into the molecular etiology of DYT12, we generated and analyzed knockout heterozygous mice(Atp1a3^<+/->). Atp1a3^<+/-> mice showed increased sensitivity to kainate-induced dystonia than wild-type littermates(WT). Electrophysiological studies showed enhanced response of Purkinje cells in Atp1a3^<+/-> at cerebellar inhibitory synapses. Our results shed light on the role of Atp1a3 in inhibitory synapse, and its potential involvement in the expression of dystonia symptoms of DYT12.

肌张力障碍的特征是激动剂和拮抗剂肌肉的同时收缩，dyt12。并分析敲除杂合小鼠（ATP1A3^+/ - >）。 。

项目成果

Postsynaptic mechanisms of CO2 responses in parafacial pre-inspiratory neurons of newborn rats

新生大鼠面旁前吸气神经元 CO2 反应的突触后机制

• DOI: 10.1113/jphysiol.2011.222687
• 发表时间: 2012
• 期刊: J.Phys.
• 作者: Onimaru;H.;Ikeda;K.;Kawakami;K.
• 通讯作者: K.

Relationship between the distribution of Phox2b expressing cells and blood vessels in the parafacial region of the ventral medulla of neonatal rats

新生大鼠腹延髓面旁区Phox2b表达细胞分布与血管的关系

• DOI: 10.1016/j.neuroscience.2012.03.037
• 发表时间: 2012
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Onimaru;H.;Ikeda;K.;Kawakami;K.
• 通讯作者: K.

Phox2b, RTN/pFRG neurons and respiratory rythmogenesis

Phox2b、RTN/pFRG 神经元和呼吸节律发生

• 发表时间: 2009
• 期刊: Resp.Physiol.Neurobiol. 168
• 作者: Onimaru;H.
• 通讯作者: H.

Menthol inhibits respiratory rhythm in the brainstem preparation of newborn rats.

薄荷醇抑制新生大鼠脑干准备中的呼吸节律。

• 发表时间: 2010
• 期刊: Neuro Rep 21
• 作者: Tani M;Onimaru H;Ikeda K;Kawakam K;Homma I.
• 通讯作者: Homma I.