Study on mother-to-child transmission of human T-lymphotropic virus type I.-Guidance for safe and proper way of breast feeding for carrier mother-

人类嗜T淋巴细胞病毒I型母婴传播研究-携带者母亲安全正确母乳喂养指南-

基本信息

批准号：
04670608
负责人：
KAWAKAMI Kiyoshi
金额：
$ 1.41万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

项目摘要

We have investigated the risk of mother-to-child transmission of human T-lymphotropic virus type I (HTLV-I) from the point of breast feeding among the children born to carrier mothers. We started the study in January 1986, and 955 children born to carrier mothers were registered. Among 955 babies, 357 follow up childern aged over 1-yaer-old were evaluated for the seropositivity of HTLV-I.Seropositivity of HTLV-I in breast feeders was 6.7%, while that in bottle feeders was 5.3%. There was no significant difference for the rate between the two groups statistically. But among those breast feeders, seroconversion occurred more frequently in the group of more than 7 months breast-fed children (long term breast feeding) than in the group of less than 6 months breast-fed children(short term breast feeding). There were statistically significant differences in the seropositivity between long term breast feeders and short term breast feeders(25.0% vs 3.2%), and between long term breast feeders and bottle feeders (25.0% vs 5.3%). Furtheremore, very short term (within 3 months) breast feeding provided the very low seroconversion rate with only 1.9%. The retrospective data from the siblings of those follow up children born to carrier mothers revealed the same results as that of follow up children.As conclusions,Short term breast feeding was suggested not to be the risk of infection of HTLV-I on mother-to-child transmission by the route of breast milk as thoght to be before starting this study. We should emphasize that short term breast feeding has the same rate of HTLV-I seroconversion as bottle feeding. And short term breast feeding may be recommended for carrier mothers, if they wish to feed their children with breast milk.

我们已经调查了从母亲在母亲出生的孩子中，从母乳喂养的点开始，人类T淋巴病毒（HTLV-I）的母亲传播的风险。我们于1986年1月开始研究，并注册了955个承运人母亲的孩子。在955个婴儿中，评估了357名年龄超过1岁的孩子的随访，评估了HTLV-I的血清阳性。在喂食器中，HTLV-I的s骨阳性为6.7％，而瓶装饲养者中的血清阳性为5.3％。两组之间的速率没有显着差异。但是在这些母乳喂养儿童（长期母乳喂养）的组中，血清转化的发生率要比不到6个月的母乳喂养儿童（短期母乳喂养）的频率更高。长期喂养器和短期喂养器（25.0％vs 3.2％）以及长期喂养器和奶瓶喂养器之间的血清阳性差异在统计学上存在显着差异（25.0％vs 5.3％）。远处的母乳（在3个月内）的母乳喂养非常短，使血清转化率仅为1.9％。从承运人母亲出生的那些随访儿童的兄弟姐妹中的回顾性数据显示出与后续儿童相同的结果。如结论，短期母乳喂养不是在母亲身上感染HTLV-I的风险 - 在开始这项研究之前，以母乳为Thoght的母乳的传播。我们应该强调的是，短期母乳喂养的HTLV-1血清转化率与瓶喂养相同。如果载体母亲想用母乳喂养孩子，则可能建议对母亲进行短期母乳喂养。