Study on oncoimmunology in carrier children of HTLV-I

HTLV-I携带者儿童肿瘤免疫学研究

• 批准号: 07670880
• 负责人: KAWAKAMI Kiyoshi
• 金额: $ 1.54万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670880/
• 关键词: HTLV-I; mother-to-child; breast feeding; 抗腫瘍免疫; 長期母乳哺育; High HTLV-I antigen-producing mother

We have investigated the transmission of human T-lymphotropic virus type I (HTLV-I) from mother-to-child for 12 years. The results are follows :1)Transmission of HTLV-I from mother-to-child occurred with the rate of 4.9% in bottle feeders, and 8.0% in breast feeders. Among breast feeders, the rate of transmission was higher in the group of more than 7 months breast-fed children than in the group of less than 6 months brestfed children (25.0% vs 2.5%). There was statistically significant differences in the rate of trans-mission between the two groups.2)Anti-HTLV-I antibody transmitted from mother, which have been detected by about 6 months after birth, was suggested to act as defensive against HTLV-I vertical infection.3)The level of soluble interleukin-2 receptor was higher in the group of HTLV-I transmitted children than that in the group of non-transmitted children born to HTLV-I carrier mothers, and that in the group of normal control children. But no significant differences was admitted between the groups, due to small numbers of children tested in those groups.4)Further investigations such as immunological studies against HTLV-I infection and human leukocyte antigens (HLA) among children born to HTLV-I carrier mothers are needed.

我们已经调查了人类至子女的I型I型（HTLV-I）的传播12年。结果如下：1）从母亲到孩子的HTLV-I的传播发生在奶瓶喂食器中为4.9％，母乳喂养者的速率为8.0％。在母乳喂养的孩子中，母乳喂养的儿童的传播率高于少于6个月的Brestfed儿童（25.0％比2.5％）的传播率高。两组之间的trans误速率在统计学上存在显着差异。 3）HTLV-I传播儿童组可溶性白介素-2受体的水平高于HTLV-I载体母亲所生的非传播儿童的水平，而在正常对照组中孩子们。但是，由于这些组中测试的儿童数量很少，两组之间没有任何显着差异。需要。

项目成果

沖 利貴ら: "南九州におけるHTLV-I母児感染の実態調査-主に授乳期間と母児感染率-" 母児感染研究論文集(HTLV-I母児感染研究会事務局発行). 6. 43-48 (1994)

大木敏树等：《九州南部HTLV-I母婴感染现状调查——主要是母乳喂养期和母婴感染率》母婴感染研究论文集（HTLV-I 母婴感染研究组秘书处出版） 6 .43-48 (1994)。

中村 茂行: "HTLV-I感染症" 小児内科. 29. 879-881 (1997)

Shigeyuki Nakamura：“HTLV-I 感染”小儿内科医学。 29. 879-881 (1997)

中村 茂行: "HTLV-Iと母子感染" 小児内科. 27(10). 1465-1468 (1995)

Shigeyuki Nakamura：“HTLV-I 和母婴传播”《儿科内科》27(10) (1995)。

嶽崎 俊郎: "母乳とウイルス感染-ATLウイルス感染-" 周産期医学. 26(4). 545-549 (1996)

Toshiro Takesaki：“母乳和病毒感染 - ATL 病毒感染 -” 围产期医学 545-549（1996）。

Toshiro Takezeki, Kiyoshi Kawakami, Mitsuko Ito, Ken-ichiro kinoshita, Kazuo Tajima: "Breast feeding and viral infectn-ATL virus infection." Shusanki Igaku. 26(4). 545-549 (1996)

Toshiro Takezeki、Kiyoshi Kawakami、Mitsuko Ito、Ken-ichiro kinoshita、Kazuo Tajima：“母乳喂养和病毒感染-ATL 病毒感染。”