Regulation of synovial cell proliferation by HGF antagonist

HGF拮抗剂对滑膜细胞增殖的调节

• 批准号: 21590187
• 负责人: IWASAKI Tsuyoshi
• 金额: $ 3万
• 依托单位: Hyogo University of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590187/
• 关键词: 関節リウマチ; 滑膜; 血管新生

Intravenous injection of AdCMV. NK4 into SKG mice suppressed the progression of s-glucan induced arthritis. Bone destructions were also inhibited by NK4 treatment. Histopathological findings of the foot joints revealed that angiogenesis, inflammatory cytokines, and RANKL expressions in synovial tissues were significantly inhibited by NK4 treatment. Molecular targeting of HGF by NK4 can therefore be potentially applied as a novel therapeutic approach for the treatment of RA.

静脉注射AdCMV。 NK4 进入 SKG 小鼠体内可抑制 s-葡聚糖诱导的关节炎的进展。 NK4 治疗也抑制了骨质破坏。足关节的组织病理学结果表明，NK4 治疗显着抑制滑膜组织中的血管生成、炎症细胞因子和 RANKL 表达。因此，NK4 对 HGF 的分子靶向可以潜在地用作治疗 RA 的新治疗方法。

项目成果

Role of HGF-c-Met signaling pathways in synovial cells for the pathogenesis of rheumatoid arthritis

滑膜细胞中HGF-c-Met信号通路在类风湿性关节炎发病机制中的作用

• 发表时间: 2011
• 作者: Tsunemi S;Iwasaki T;Kitano M;K. Matsumoto K;Sano H.
• 通讯作者: Sano H.

HGF antagonist, NK4, inhibits Th1 immune response, RANKL expression on synovial fibroblasts

HGF 拮抗剂 NK4 抑制滑膜成纤维细胞上的 Th1 免疫反应和 RANKL 表达

• 发表时间: 2009
• 作者: Tsunemi S;Iwasaki T;Kitano S;Sano H.
• 通讯作者: Sano H.