Control of immune reactions associated with transplantation by hepatocyte growth factor and edg-1 ligand

肝细胞生长因子和edg-1配体控制与移植相关的免疫反应

• 批准号: 17591017
• 负责人: IWASAKI Tsuyoshi
• 金额: $ 2.24万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591017/
• 关键词: Edg-1; FTY720; GVHD; HGF; 造血幹細胞移植; SIP

1) FTY720 treatment reduced the numbers of peripheral blood lymphocytes2) Combination treatment with HGF and FTY720 significantly prevented intestinal damages caused by acute GVHD, thereby prolonged the survival of GVHD mice.3) Combination treatment with HGF and FTY720 significantly prevented thymic damages caused by acute GVHD, thereby prolonged the survival of GVHD mice.4) Combination treatment with HGF and FTY720 significantly reduced TNF-a and IFN-y mRNA expressions in the intestine of acute GVHD mice.5) FTY treatment prevented chronic GVHD.

1）FTY720治疗减少了外周血淋巴细胞的数量2）HGF和FTY720联合治疗显着预防急性GVHD引起的肠道损伤，从而延长GVHD小鼠的生存期。3）HGF和FTY720联合治疗显着预防急性GVHD引起的胸腺损伤GVHD，从而延长GVHD小鼠的存活时间。4）HGF和FTY720联合治疗显着降低TNF-a和急性GVHD小鼠肠道中IFN-γ mRNA的表达。5)FTY治疗可预防慢性GVHD。

项目成果

Hepatocyte growth factor prevents lupus nephritis in murine lupus model of chronic graft-versus-host disease.

肝细胞生长因子可预防慢性移植物抗宿主病的小鼠狼疮模型中的狼疮性肾炎。

• 发表时间: 2006
• 期刊: Arthritis Res Ther 8
• 作者: Kuroiwa T;Iwasaki T;Imado T;Sekiguchi M;Fujimoto J;Sano H
• 通讯作者: Sano H

Sphingosine 1-phosphate/sphingosine 1-phosohate receptor 1 signaling in rheumatoid synovium : regulation of synovial proliferation and inflammatory gene expression.

类风湿滑膜中的 1-磷酸鞘氨醇/1-磷酸鞘氨醇受体 1 信号传导：滑膜增殖和炎症基因表达的调节。

• 发表时间: 2006
• 期刊: Arthritis Rheum 54
• 作者: Kitano M;Hla T;Sekiguchi M;Kawahito Y;Iwasaki T;Sano H et al.
• 通讯作者: Sano H et al.

Protective growth factors for graft-versus-host disease

移植物抗宿主病的保护性生长因子

• 发表时间: 2005
• 期刊: Hematopoietic stem cell transplantation and graft-versus-host disease (Iwasaki T ed) (Bentham Science Publishers)
• 作者: Kawabata H;Tomosugi N;Kanda J;Tanaka Y;Yoshizaki K;Uchiyama T.;Iwasaki T
• 通讯作者: Iwasaki T

Hematopoietic stem cell transplantation and graft-versus-host disease

造血干细胞移植和移植物抗宿主病

• 发表时间: 2005
• 作者: Tomosugi N;Kawabata H;Wakatabe R;Higuchi M;Yamaya H;Umehara H;Ishikawa I;Iwasaki T
• 通讯作者: Iwasaki T