Cytochemical and molecular biological analysis of neurosteroid synthesis and action mechanism in the hippocampus

海马神经甾体合成及作用机制的细胞化学和分子生物学分析

• 批准号: 20590192
• 负责人: ISHIMURA Kazunori
• 金额: $ 3.08万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590192/
• 关键词: 細胞組織化学; 海馬; 神経ステロイド; 免疫組織化学; アロマターゼ; 神経細胞; エストロゲン受容体; 卵巣摘除; ニューロン新生; 細胞組織化学; 海馬; 神経ステロイド; 免疫組織化学; アロマターゼ; 神経細胞; エストロゲン受容体; 卵巣摘除; ニューロン新生

To elucidate the physiological role of neurosteroid that was produced in the central nerve system, we analyzed the expression of steroid hormone synthesizing enzymes and receptors in the hippocampus. As a result of immunohistochemical analysis, several enzymes and receptors were localized in nerve cells in the hippocampus. Change of aromatase expression level suggests that aromatase may be regulated by the steroid hormone produced in peripheral endocrine glands.

为了阐明在中央神经系统中产生的神经类固醇的生理作用，我们分析了海马中类固醇激素合成酶和受体的表达。由于免疫组织化学分析，将几种酶和受体定位在海马的神经细胞中。芳香酶表达水平的变化表明，芳香酶可以受到周围内分泌腺体产生的类固醇激素的调节。