Investigation on regulation of the human blood group ABO gene transcription with a novel antisense RNA transcribed from the opposite strand

反义链转录的新型反义RNA对人血型ABO基因转录调控的研究

• 批准号: 19390183
• 负责人: KOMINATO Yoshihiko
• 金额: $ 10.65万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390183/
• 关键词: 血液型; ABO式血液型遺伝子; 転写因子CTCF; クロマチンリモデリング; ABO式血液型; 転写調節; non-coding RNA; 遺伝子; 糖転移酵素; 遺伝学; 癌; 糖鎖; 発現制御

We found a novel antisense RNA transcribed from the opposite strand of the human blood group ABO gene, and showed that the ABO and ABOAS transcripts appeared to exhibit reciprocal expression patterns in the cells expressing the ABO gene. These results suggest that ABOAS transcribed from the opposite strand of the ABO gene might be involved in the regulation of ABO gene expression.

我们发现了一种从人类血型 ABO 基因的相反链转录而来的新型反义 RNA，并表明 ABO 和 ABOAS 转录物似乎在表达 ABO 基因的细胞中表现出相反的表达模式。这些结果表明，从 ABO 基因相反链转录的 ABOAS 可能参与 ABO 基因表达的调节。

项目成果

Development of a sensitive enzyme-linked immunosorbent assay for measurement of DNase I in human serum.

• DOI: 10.1016/j.cca.2009.03.005
• 发表时间: 2009-05
• 期刊: Clinica chimica acta; international journal of clinical chemistry
• 作者: T. Nakajima;Rie Takagi;Yutaka Tajima;C. Makita;Y. Kominato;J. Kuribara;S. Ohshima;H. Tada;H. Tsurugaya;Yasuyuki Kobayashi;H. Takeshita;Yasuyuki Kawai;T. Yasuda

Development of Genotyping Methods for Single Nucleotide Polymorphism in the Human Pancreatic Ribonuclease Gene (RNASE1) and Their Application to Population Studies

• DOI: 10.1007/s10528-007-9138-2
• 发表时间: 2008-01
• 期刊: Biochemical Genetics
• 影响因子: 2.4
• 作者: M. Ueki;R. Iida;J. Fujihara;H. Takeshita;I. Yuasa;Y. Kominato;T. Yasuda

ABO遺伝子の発現制御におけるポリADP-リボシル化の関与の検討

多 ADP 核糖基化参与 ABO 基因表达调节的研究

• 发表时间: 2007
• 作者: 畑由紀子;小湊慶彦;松井一裕;島田一郎;滝沢久夫
• 通讯作者: 滝沢久夫

Immunohistochemical study of thyroid transcription factor-1 and surfactant-associated protein A for investigation of periphe- ral airway structure in perinatal fatality

甲状腺转录因子 1 和表面活性剂相关蛋白 A 的免疫组织化学研究，用于研究围产期死亡的外周气道结构

• 发表时间: 2008
• 期刊: Legal Med 10
• 作者: Shimada I;Matsui K;Kominato Y;Hata Y;Takizawa H;Nishida N.
• 通讯作者: Nishida N.

A case of acute myocardial infarction after intracoronary stent implantation : demonstration of the stent location by postmortem X-ray examination

冠状动脉内支架植入后急性心肌梗死一例：尸检X线检查显示支架位置

• 发表时间: 2009
• 期刊: Legal Medcine
• 作者: Tajima Y;Takagi R. Kominato Y
• 通讯作者: Takagi R. Kominato Y