Molecular dissection of the vector-parasite relationship using Aedes-Filaria transmission system

利用伊蚊-丝虫传播系统对媒介-寄生虫关系进行分子解剖

• 批准号: 19380165
• 负责人: FUKUMOTO Shinya
• 金额: $ 12.9万
• 依托单位: Obihiro University of Agriculture and Veterinary Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19380165/
• 关键词: イヌ; フィラリア; ヤブカ; 寄生虫; 宿主適応

The host -parasite relationship in vector mosquito, Aedes, and Filaria parasite was analyzed. Our data indicated that the mosquito innate immune systems were not significantly affect filarial infection to mosquito vector. This result suggested the presence of completely different anti-pathogen system against filarial parasite compare to small pathogens such as protozoa, bacteria or virus. The molting related genes of filarial parasite were considered as have a key role for host transition. Especially, cut1 gene transcripts were specifically detected in host transition stage. This result indicated that cut1 could be a useful drug target for establishing novel filarial parasite infection controlling strategy.

分析了媒介蚊子，艾德斯和filaria寄生虫中的寄主 - 寄生虫关系。我们的数据表明，蚊子先天免疫系统并未显着影响对蚊子载体的丝状感染。该结果表明，与原生动物，细菌或病毒等小病原体相比，存在完全不同的抗病原体系统针对丝状寄生虫。丝状寄生虫的摩尔相关基因被认为是宿主转变的关键作用。特别是在宿主过渡阶段特别检测到Cut1基因转录本。该结果表明，CUT1可能是建立新型丝状寄生虫感染控制策略的有用药物。

项目成果

Furrowed/CTLSE1 aborts development of Plasmodium parasite in Anopheles gambiae

Furrowed/CTLSE1 阻止冈比亚按蚊疟原虫寄生虫的发育

• 发表时间: 2007
• 作者: 新澤直明;嘉糠洋陸;Kanuka H. et al.;Kanuka H. et al.;Nelson B. et al.;嘉糠洋陸;嘉糠洋陸;嘉糠洋陸;嘉糠洋陸
• 通讯作者: 嘉糠洋陸

Fly Immunity: Diversity of Drosophila Susceptibility to Bacterial Infection

苍蝇免疫：果蝇对细菌感染易感性的多样性

• 发表时间: 2007
• 作者: 岡戸清;新澤直明;青沼宏佳;福本晋也;嘉糠洋陸
• 通讯作者: 嘉糠洋陸

Filarial parasites : developmental transition mechanism mediated by environmental stimuli during a bridge between vector and host

丝虫寄生虫：在载体和宿主之间的桥梁期间由环境刺激介导的发育过渡机制

• 发表时间: 2009
• 作者: Aya Yoshimura;Kiyoshi Okado;Kazumasa Hada;Ryusuke Niwa;Shinya Fukumoto;Hirotaka Kanuka
• 通讯作者: Hirotaka Kanuka

フィラリアの環境応答性トランジション機構の解明

阐明丝虫的环境响应转变机制

• 发表时间: 2009
• 作者: 吉村文;福本晋也;嘉糠洋陸
• 通讯作者: 嘉糠洋陸

Immunogenicity and growth inhibitory efficacy of the prime-boost immunization regime with DNA followed by recombinant vaccinia virus carrying the P29 gene of Babesia gibsoni in dogs

• DOI: 10.1016/j.exppara.2009.08.012
• 发表时间: 2009-12-01
• 期刊: EXPERIMENTAL PARASITOLOGY
• 影响因子: 2.1
• 作者: Fukumoto, Shinya;Tamaki, Yoh;Xuan, Xuenan
• 通讯作者: Xuan, Xuenan