NIRS and MEG study on brain mechanisms of social cognitive deficits in schizophrenia and mood disorders

NIRS 和 MEG 研究精神分裂症和情绪障碍社会认知缺陷的脑机制

• 批准号: 18390318
• 负责人: FUKUDA Masato
• 金额: $ 3.92万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390318/
• 关键词: near-infrared spectroscopy; magnetoencephalography; schizophrenia; mood disorders; social cognition

Objectives: Near-infrared spectroscopy (NIBS) is a recently developed technology that monitors cerebral blood volume changes noninvasively in bedside setting. NIRS has been increasingly employed in psychiatry such as functional neuroimaging studies of personality, aging, and psychiatric disorders. Characteristics of frontal lobe function were investigated using multichannel NIRS machines in schizophrenia, unipolar depression, and bipolar depression.Methods: Twenty-five patients with schizophrenia, eleven patients with unipolar depression, seventeen patients with bipolar depression, and their age- and sex-matched healthy subjects participated in the study after giving their written informed consents. Changes of oxy-hemoglobin concentration ( [oxy-Hb] ) were monitored every 0.1 s during a word fluency task and a finger-tapping task using two sets of 24-channel NIRS machines (Hitachi Medical Co.) with the probes placed on the subjects' frontal and the bilateral temporal regions.Results: Three psychiatric groups demonstrated different patterns of [oxy-Hb] changes from those in the control group during the word fluency task although their task performances were equal. The schizophrenic group was characterized by reduced [oxy-Hb] increase during the task period followed by [oxy-Hb] re-increase during the post-task period, the unipolar depression group by smaller [oxy-Hb] increase, and the bipolar depression group by comparable but delayed [oxy-Hb] increase.Conclusions: The observed differences of [oxy-Hb] changes suggest the characteristics in time courses of reactivity of frontal lobe function: inefficient, reduced, and preserved but delayed activation in schizophrenia, unipolar depression, and bipolar depression, respectively. NIRS has revealed detailed time-courses of frontal lobe activation, and can be employed as a clinical laboratory test for diagnosis and treatment of psychiatric disorders in the near future.

目的：近红外光谱法（NIBS）是一项最近开发的技术，可在床边环境中无创地监测脑血容量变化。 NIRS越来越多地从事精神病学，例如对人格，衰老和精神疾病的功能神经影像学研究。使用精神分裂症，单极抑郁症和躁郁症抑郁症的多通道NIR机器研究了额叶功能的特征。方法：二十五名精神分裂症患者，11例单极抑郁症患者，双极性抑郁症患者具有双极抑郁症患者，患有年龄和性别的健康受试者，并在研究中为他们提供了著名的认可。在单词流畅性任务期间每0.1 s监测氧气血红蛋白浓度（[[oxy-hb]）的变化，并使用两组24通道NIRS机器（Hitachi Medical Co.）进行手指敲击任务，并通过对受试者的额叶和双边临时组的探针进行探针，并在此过程中进行了三个不同的模式。流利的任务尽管他们的任务表现相等。精神分裂症群的特征是在任务期间[氧hb]在任务后的[oxy-hb]在后期的[oxy-hb]重新加入，单极抑郁群，单极抑郁群的增加，较小的[oxy-hb]增加[oxy-hb]增加[oxy-hb]，而双极性抑郁群则通过可比但延迟的[oxy-hb]增加[oxy-hb]的增加。精神分裂症，单极抑郁症和躁郁症抑郁症分别效率低下，降低和保留但延迟激活。 NIRS揭示了额叶激活的详细时间仪，并可以用作临床实验室测试，以便在不久的将来诊断和治疗精神疾病。

项目成果

Relationship between age at onset and magnetic resonance image (MRI)-defined hyperintensities in mood disorders

情绪障碍中发病年龄与磁共振图像 (MRI) 定义的高信号之间的关系

• 发表时间: 2008
• 期刊: j Psychiatr Res 42
• 作者: Takahashi K;Oshima A;Ida I;Kumano H;Yuuki N;Fukuda M;Amanuma A;Endo K;Mikuni M
• 通讯作者: Mikuni M

Phonetic mismatch negativity predicts social skills acquisition in schizophrenia

• DOI: 10.1016/j.psychres.2006.02.010
• 发表时间: 2007-08-30
• 期刊: PSYCHIATRY RESEARCH
• 影响因子: 11.3
• 作者: Kawakubo, Yuki;Kamio, Satoru;Kasai, Kiyoto
• 通讯作者: Kasai, Kiyoto

Comparison between mismatch negativity amplitude and magnetic mismatch field strength in normal adults

• DOI: 10.1016/j.biopsycho.2005.01.011
• 发表时间: 2006-01
• 期刊: Biological Psychology
• 影响因子: 2.6
• 作者: Noriko Kudo;K. Kasai;K. Itoh;I. Koshida;M. Yumoto;Masato Kato;S. Kamio;T. Araki;K. Nakagome;M. Fukuda;H. Yamasue;Haruyasu Yamada;O. Abe;N. Kato;A. Iwanami

Decreased cortical reactivity underlies subjective daytime light sleepiness in healthy subjects: A multichannel near-infrared spectroscopy study

• DOI: 10.1016/j.neures.2007.12.001
• 发表时间: 2008-03-01
• 期刊: NEUROSCIENCE RESEARCH
• 影响因子: 2.9
• 作者: Suda, Masashi;Sato, Toshimasa;Mikuni, Masahiko
• 通讯作者: Mikuni, Masahiko

近赤外線スペクトロスコピィ(NIRS)の精神疾患への応用

近红外光谱（NIRS）在精神疾病中的应用

• 发表时间: 2006
• 作者: Nagata;Y;福田正人
• 通讯作者: 福田正人