Establishment of in situ functional neuroimaging for social Behavior and its application to psychiatry

社会行为原位功能神经影像的建立及其在精神病学中的应用

• 批准号: 22659209
• 负责人: FUKUDA Masato
• 金额: $ 2.04万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659209/
• 关键词: 統合失調症; 気分障害; 対人関係; 近赤外線スペクトロスコピィ; 前頭極; 脳・神経; 脳神経疾患; 前頭葉; 対人行動; 統合失調症; 気分障害; 対人関係; 近赤外線スペクトロスコピィ; 前頭極; 脳・神経; 脳神経疾患; 前頭葉; 対人行動

Brain substrates of social behavior were investigated using near-infrared spectroscopy (NIRS) just during the conversation. Frontal and temporal activations during the conversation were correlated positively with cooperativeness assessed with the NEO-PI-R and negatively with autistic trait assessed with the autism quotient (AQ) in healthy subjects, and were also negatively correlated with negative symptoms assessed with the PANSS in schizophrenia patients. These results demonstrate successful establishment of functional neuroimaging examination just during social behaviors, which can be called as "in situ neuroimaging".

仅在对话期间，使用近红外光谱（NIR）研究了社会行为的脑部底物。对话期间的额叶和时间激活与与NEO-PI-R评估的合作性相关，并在健康受试者中与自闭症商（AQ）评估的自闭症特征负相关，并且与精神分裂症患者的PANSS评估的负面症状负相关。这些结果表明，仅在社会行为期间，成功建立了功能神经影像检查检查，这可以称为“原位神经影像”。