Clarification of hemodynamic features in frontal lobes in psychiatric disorders : multi-channel near-infrared spectroscopy study

精神疾病额叶血流动力学特征的澄清：多通道近红外光谱研究

基本信息

批准号：
13670982
负责人：
FUKUDA Masato
金额：
$ 1.79万
依托单位：
Gunma University Graduate School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

Background : Hemodynamic features of frontal lobes in depression, bipolar disorders, and schizophrenia were examined using recently developed multichannel near-infrared spectroscopy (NIRS) which can measure cerebral blood volumes simultaneously in multiple points with high time resolution. Methods : Eleven patients with depression, eight patients with bipolar disorders, thirteen patients with schizophrenia, and fifteen healthy volunteers participated in the study after giving their written informed consent. Relative concentrations of oxy-hemoglobin ([oxy-Hb]) were measured by the frontal and the bilateral temporal probes every 0.1 second during a word fluency task and a unilateral finger tapping task using two sets of 24-channel NIRS machines. The obtained [oxy-Hb data were averaged for each group and between-group differences were examined. Results : The [oxy-Hb] increase patterns during the word fluency task varied among the four groups although their task performances were similar : compared with the [oxy-Hb] change pattern in the control group, the depression group was characterized by a smaller [oxy-Hb] increase during the first half of the task period, the bipolar group by prolonged [oxy-Hb] peak latency with similar amplitude, and the schizophrenic group by an [oxy-Hb] re-increase in the post-task period. The differences were task-specific because [oxy-Hb] change patterns during the finger tapping task were similar across the four groups. Conclusions : The observed characteristic patterns of [oxy-Hb] changes in the frontal lobe were assumed to reflect the brain function features of psychiatric disorders. The NIRS methodology with its noninvasiveness and high-time resolution can be a useful tool for establishing biological markers for diagnosis and treatment of psychiatric disorders in clinical practice.

背景：使用最近开发的多通道近红外光谱（NIR）检查抑郁，躁郁症和精神分裂症中额叶的血液动力学特征，这些特征可以在多个点以高时间分辨率的多个点同时测量大脑血量。方法：11例抑郁症患者，8例躁郁症患者，十三例精神分裂症患者以及15名健康志愿者在给予书面知情同意后参加了这项研究。在单词流利任务中，每0.1秒以及使用两组24频道NIRS机器在单词流利度任务中每0.1秒通过额叶和双侧时间探针测量氧气血红蛋白（[oxy-hb]）的相对浓度。为每个组平均获得的[氧HB数据，并检查了组间差异。 Results : The [oxy-Hb] increase patterns during the word fluency task varied among the four groups although their task performances were similar : compared with the [oxy-Hb] change pattern in the control group, the depression group was characterized by a smaller [oxy-Hb] increase during the first half of the task period, the bipolar group by prolonged [oxy-Hb] peak latency with similar amplitude, and the schizophrenic group by an [oxy-Hb] re-increase in任务后期。这些差异是特定于任务的，因为在四组中，[氧hb]在手指敲击任务期间的变化模式相似。结论：假定额叶[氧hb]变化的观察到的特征模式反映了精神疾病的脑功能特征。 NIRS方法论具有无创和高时间分辨率，可以是建立用于诊断和治疗精神疾病的临床实践中的生物标记的有用工具。