The study of the association of immune related genotypes with dental caries in Japanese individuals

日本人免疫相关基因型与龋齿相关性的研究

基本信息

批准号：
17592174
负责人：
CHIBA Junko
金额：
$ 2.11万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

The literature is replete with evidence supporting that human dental caries, an infectious disease of bacterial origin, can be preventable by mucosal immunization. Recently, significant genetic contribution to caries progression and severity was reported in a twin study. However, it has not been reported to confirm the association of certain immune related genotypes with caries susceptibility. The purpose of the present study was to confirm the association of certain immune related genotypes with caries susceptibility in Japanese individuals. Human leukocyte antigens (HLAs) play an important role in regulating the immune system. A total of 104 children aged 10 yrs (48 children with caries and 56 children without caries) were included to examine the susceptibility to early onset caries. The HLA・DQB1*03/*05 genotypes were significantly associated with dental caries susceptibility (P=0.005, Pc=0.004). The DRB1*04/*15 genotypes were significantly associated with dental caries susceptibility in a total of 135 children aged 13 yrs (75 children with caries and 60 children without caries) (P=0.0045, Pc=0.04). The HLA-DQB1*06/*06 genotypes were significantly associated with dental caries susceptibility in a total of 164 subjects, aged 26 yrs or younger (mean age, 20.4 ±2.2, 98 adolescents with caries and 66 adolescents without caries) (P=O.0027, Pc=0.027). In conclusion, this study using a cohort of a 10-year old, 13-year-old children, and adolescents with and without caries demonstrated the possible effect of specific HLA genotype on dental caries progression.

文献中有大量证据表明，人类龋齿是一种细菌来源的传染病，可以通过粘膜免疫来预防。最近，一项双胞胎研究报道了遗传因素对龋齿进展和严重程度的显着影响。确认某些免疫相关基因型与龋齿易感性的关联本研究的目的是确认某些免疫相关基因型与日本人的人类白细胞抗原（HLA）的关联。共有 104 名 10 岁儿童（48 名患有龋齿的儿童和 56 名未患龋齿的儿童）参与了对早发龋齿的易感性研究。 DRB1*04/*15 基因型与龋齿易感性显着相关（P=0.005，Pc=0.004）。 135名13岁儿童中存在龋齿易感性（75名有龋齿儿童，60名无龋齿儿童）（P=0.0045，Pc=0.04），HLA-DQB1*06/*06基因型与龋齿显着相关。总共 164 名 26 岁或以下受试者（平均年龄 20.4 ±2.2，98 名患有龋齿的青少年和 66 名没有龋齿的青少年）（P=O.0027，Pc=0.027）总之，本研究使用了 10 岁、13 岁儿童和患有龋齿的青少年队列。没有龋齿则证明了特定 HLA 基因型对龋齿进展的可能影响。