Risk factors for puberty gingivitis (Influence of cytokine)

青春期牙龈炎的危险因素（细胞因子的影响）

• 批准号: 14571937
• 负责人: CHIBA Junko
• 金额: $ 2.18万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571937/
• 关键词: Puberty gingivitis; Dental calculus; Gingival bleeding; Salivary flow rate; HLA gene polymorphism; IL-1(-511) gene polymorphism; TGF-B(-509) gene polymorphism; Risk factor for gingivitis; サイトカイン遺伝子型; DNA; 分子疫学; 性ホルモン受容体遺伝子型; TaqMan PCR法; HLA

The aim of this study was to examine the risk factor of puberty gingivitis. A total of 77 Japanese children (25 boys, 52 girls), aged 13 years, were examined. Calculus, gingival bleeding on probing, and gingival pocket depth were used to assess gingivitis. Stimulated salivary flow rate and unstimulated salivary flow rate were measured. Plaque Control Record (PCR) index were also examined. DNA was obtained from buccal epithelial cells. A single dentist carried out the dental examinations looking for gingival bleedings after probing, calculus and gingival pockets. The associations between gingival conditions, calculus, PCR index, stimulated salivary flow rate, unstimulated salivary flow rate, height, age of menarche, HLA gene polymorphism, IL-1 (-511) gene polymorphism, and TGF-B (-509) gene polymorphism were analyzed. The prevalence of gingival bleeding and calculus were 31.2%, and 40.3%, respectively. Gingival pockets were 1-2 mm in all students. There were no associations between gingival bleeding and PCR index, and also between calculus and PCR index. Calculus was associated with gingival bleeding in boys only, and with stimulated salivary flow rate. Salivary flow rate was associated with the combination of with and without gingival bleeding and calculus. Height and age of menarche were associated with gingival bleeding teeth in girls. The HLA-DQB1^*04 allele was significantly more common in students with gingival bleeding, while HLA-DQB1^*05 allele was significantly more common in students with calculus. There were no associations between gingival conditions and IL-1 (-511) gene polymorphisms. TGF-B (-509) genotype (T/T, T/C, and C/C) was associated with calculus in boys. These data suggest that salivary flow rate, height, age of menarche, HLA-DQB1 gene polymorphism, and TGF-B (-509) gene polymorphisms could be a risk factor for gingivitis.

本研究的目的是检查青春期牙龈炎的危险因素。共有 77 名 13 岁的日本儿童（25 名男孩，52 名女孩）接受了检查。使用牙石、探诊牙龈出血和龈袋深度来评估牙龈炎。测量刺激唾液流速和未刺激唾液流速。还检查了噬菌斑控制记录（PCR）指数。 DNA 是从颊上皮细胞中获得的。一位牙医进行了牙科检查，探诊后寻找牙龈出血、牙石和牙龈袋。牙龈状况、牙结石、PCR指数、刺激唾液流速、非刺激唾液流速、身高、初潮年龄、HLA基因多态性、IL-1（-511）基因多态性和TGF-B（-509）基因之间的关联进行了多态性分析。牙龈出血和牙石的患病率分别为31.2%和40.3%。所有学生的龈袋厚度均为 1-2 毫米。牙龈出血和 PCR 指数之间以及牙结石和 PCR 指数之间都没有关联。牙结石仅与男孩的牙龈出血有关，并且与刺激的唾液流量有关。唾液流量与有无牙龈出血和牙石的组合有关。初潮的高度和年龄与女孩牙龈出血的牙齿有关。 HLA-DQB1^*04 等位基因在牙龈出血的学生中显着更常见，而 HLA-DQB1^*05 等位基因在患有牙结石的学生中显着更常见。牙龈状况与 IL-1 (-511) 基因多态性之间没有关联。 TGF-B (-509) 基因型（T/T、T/C 和 C/C）与男孩牙结石相关。这些数据表明唾液流量、身高、初潮年龄、HLA-DQB1 基因多态性和 TGF-B (-509) 基因多态性可能是牙龈炎的危险因素。