Academic research project on oncogenic factors in malignant tumors in the eastnorthern China

中国东北地区恶性肿瘤致癌因素学术研究项目

• 批准号: 16406006
• 负责人: HASUI Kazuhisa
• 金额: $ 6.34万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16406006/
• 关键词: International co-operative study; The east-northern China; Nasopharyngeal malignant tumors; Nasal type NK; T-cell lymphomas; Clinicopathological study; Histochemical analysis; EBV; External oncogenic factors; 鼻NK; T細胞性リンパ腫; 幹細胞の組織化学; 細胞死の組織化学; International co-operative study; The east-northern China; Nasopharyngeal malignant tumors; Nasal type NK; T-cell lymphomas; Clinicopathological study; Histochemical analysis; EBV; External oncogenic factors; 鼻NK; T細胞性リンパ腫; 幹細胞の組織化学; 細胞死の組織化学

This academic survey project of oncogenic factors in malignant tumors the east-northern China investigated nasal malignant lymphomas (MLs) examined in the Department of Pathology, China Medical University in Shenyoung. Most of the MLs were Epstein-Barr virus (EBV)-related nasal type NK/T-cell MLs. Most of the lymphomas cells were positive for CD3ε, cytotoxic granulessuch as TIA-1 and CD56 but were negative for LAT-1 that labels NK/T-cells. The degenerative tendency in this MLs was characterized by many intermingling CD204 (Scavenger receptor)-positive macrophages, few cleaved caspase-3-positive apoptotic cells and many cells with high autophagy that was labeled by means of enzymatic antigen retrieval and supersensitive immunohistochemistry of beclin-1. In 134 cases diagnosed clinically as nasal lymphomas for 7 years from 2001, many EBV-related nasal type NK/T-cell MLs and some EBV-related B-cell MLs occurred much frequently in the nose than in the pharynx whereas there were EBV-not-related minute squamous carcinomas in the nose and EBV-related ones in the pharynx. On the other hand, in the skin in this restrict no nasal type NK/T MLs and many CD30-positive primary cutaneous lymphproliferative lesions were noted in a small-sized survey. Taken together, it was suggested that there were external oncogenic factors such as pesticides reported by Aozasa besides EBV infections. As for the oncogenic factors in nasal type NK/T MLs the oncogenic factors were thought as the exposure to the external factors, the differences in their exposure effects between the nose and the pharynax, possible appearance of peculiar sugar/mucin materials in the inflammation in the nose and induction of NK/T cells that can detect such sugar/mucin materials. These oncogenic factors must be studied further.

这项对恶性肿瘤致癌因素的学术调查项目调查了中国东北部调查了在卑诗省中国医科大学病理学系检查的鼻恶性淋巴瘤（MLS）。大多数ML是爱泼斯坦 - 巴尔病毒（EBV）相关的NK/T细胞MLS。大多数淋巴瘤细胞对CD3ε，细胞毒性颗粒（例如Tia-1和CD56）呈阳性，但对标记NK/T细胞标记的LAT-1为阴性。该MLS中的退化趋势的特征是许多混合CD204（清道夫接收器）阳性巨噬细胞，很少的裂解caspase-3阳性凋亡细胞和许多具有高可自噬的细胞，这些细胞被酶促的抗原检测和超级敏感的免疫组织物质标记。 In 134 cases diagnosed clinically as nasal lymphomas for 7 years from 2001, many EBV-related nasal type NK/T-cell MLs and some EBV-related B-cell MLs occurred much frequently in the nose than in the pharynx whereas there were EBV-not-related minute squamous carcinomas in the nose and EBV-related ones in the pharynx.另一方面，在这种限制的皮肤中，没有鼻部型NK/T mLS，许多CD30阳性的原发性皮肤淋巴细胞增长病变在小型调查中被发现。综上所述，有人提出，除了EBV感染外，还有外部致癌因素，例如Aozasa报告的农药。至于鼻型NK/T MLS中的致癌因子，致癌因子被认为是暴露于外部因素，其鼻子和咽之间的暴露作用差异，鼻子注射中特殊糖/粘蛋白材料可能出现的NK/T细胞诱导的NK/T细胞中可能检测此类糖/粘液含量的NK/T细胞。这些致癌因素必须进一步研究。