Academic research project on oncogenic factors in malignant tumors in the eastnorthern China

中国东北地区恶性肿瘤致癌因素学术研究项目

基本信息

批准号：
16406006
负责人：
HASUI Kazuhisa
金额：
$ 6.34万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16406006/
关键词：
International co-operative study The east-northern China Nasopharyngeal malignant tumors Nasal type NK T-cell lymphomas Clinicopathological study Histochemical analysis EBV External oncogenic factors 鼻NK T細胞性リンパ腫幹細胞の組織化学細胞死の組織化学

项目摘要

This academic survey project of oncogenic factors in malignant tumors the east-northern China investigated nasal malignant lymphomas (MLs) examined in the Department of Pathology, China Medical University in Shenyoung. Most of the MLs were Epstein-Barr virus (EBV)-related nasal type NK/T-cell MLs. Most of the lymphomas cells were positive for CD3ε, cytotoxic granulessuch as TIA-1 and CD56 but were negative for LAT-1 that labels NK/T-cells. The degenerative tendency in this MLs was characterized by many intermingling CD204 (Scavenger receptor)-positive macrophages, few cleaved caspase-3-positive apoptotic cells and many cells with high autophagy that was labeled by means of enzymatic antigen retrieval and supersensitive immunohistochemistry of beclin-1. In 134 cases diagnosed clinically as nasal lymphomas for 7 years from 2001, many EBV-related nasal type NK/T-cell MLs and some EBV-related B-cell MLs occurred much frequently in the nose than in the pharynx whereas there were EBV-not-related minute squamous carcinomas in the nose and EBV-related ones in the pharynx. On the other hand, in the skin in this restrict no nasal type NK/T MLs and many CD30-positive primary cutaneous lymphproliferative lesions were noted in a small-sized survey. Taken together, it was suggested that there were external oncogenic factors such as pesticides reported by Aozasa besides EBV infections. As for the oncogenic factors in nasal type NK/T MLs the oncogenic factors were thought as the exposure to the external factors, the differences in their exposure effects between the nose and the pharynax, possible appearance of peculiar sugar/mucin materials in the inflammation in the nose and induction of NK/T cells that can detect such sugar/mucin materials. These oncogenic factors must be studied further.

这项中国东北部恶性肿瘤致癌因素学术调查项目对中国医科大学病理科检查的鼻部恶性淋巴瘤（ML）进行了调查，大多数ML与EB病毒（EBV）相关。大多数淋巴瘤细胞的 CD3ε、细胞毒性颗粒（例如 TIA-1 和 CD56）呈阳性，但 NK/T 细胞 ML 呈阴性。标记 NK/T 细胞的 LAT-1 的退化趋势的特点是许多混合的 CD204（清道夫受体）阳性巨噬细胞、少量裂解的 caspase-3 阳性凋亡细胞和许多具有高自噬性的细胞。酶抗原修复和beclin-1超敏免疫组化方法在临床诊断为鼻淋巴瘤的134例中的应用。从2001年起的7年里，许多与EBV相关的鼻型NK/T细胞ML和一些与EBV相关的B细胞ML在鼻中发生的频率高于在咽部，而鼻中存在与EBV无关的微小鳞状细胞癌另一方面，在皮肤中，鼻型 NK/T ML 和许多 CD30 阳性的原发性皮肤淋巴增生性病变。一项小型调查显示，除 EBV 感染外，还有 Aozasa 报道的农药等外部致癌因素。暴露于外部因素，鼻子和咽部暴露效果的差异，鼻子炎症中可能出现特殊的糖/粘蛋白物质，以及诱导能够检测这种糖/粘蛋白的NK/T细胞这些致癌因素必须进一步研究。