Development of intravascular shock wave thrombolysis for cerebral embolism

血管内冲击波溶栓治疗脑栓塞的研究进展

基本信息

批准号：
11357014
负责人：
YOSHIMOTO Takashi
金额：
$ 14.72万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A).
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11357014/
关键词：
cerebral embolism convex-lens pointed fibrinolvsis laser-induced bubble liquid jet pulsed Ho : YAG laser Qswitch shock wave 閉塞性脳血管障害衝撃波工学レーザー医学

项目摘要

As advancing neurological images such as diffusion magnetic resonance imaging and single photon emission computed tomography, the patients having cerebral infarction within several hours after onset have been detectable. Since the therapeutic time window of cerebral infarction is generally thought to be within several hours, it is necessary to accomplish recanalization of occluded cerebral arteries with a little fibrinolytics as soon as possible.Fibrinolysis with a liquid jet induced by interaction between bubble and shock wave was succeeded in-vitro. In order to improve this technology for clinical application, A Q-switch pulsed Holmium : YAG laser was selected. This laser had 200 ns pulse duration and 2.1 mm wavelength. Energy range of this laser was variable from 36 to 150 mJ/pulse. The laser beam was transmitted through an optical fiber which diameter was 0.6 mm. In the present experiment, this laser irradiation at 86 mJ/pulse in water induced a strong shock wave over 100 atm and a … More transient spherical bubble, which can penetrate into an artificial thrombus forming a jet. In order to obtain a stronger shock wave and a larger bubble, optical fibers with three types of end surface ; a convex-lens, a coarse flat, and smooth flat were prepared and studied. The optical fiber with a convex lens-shaped end produced a shock wave with stronger overpressure and a larger bubble than that of the other ends. Regarding to two flat end surfaces, there was no difference in overpressure of a shock wave and bubble volume between smooth and coarse.A laser-induced bubble in a glass tube which diameter was 4mm was observed. The bubble gradually expanded and reached at maximum size at about 1 ms while a bubble in a large vessel did at about 300 μs. Based on this result, interaction between a shock wave induced by silver azide explosion and the laser-induced maximum bubble was attempted. The bubble was transformed to a liquid jet, which could penetrate into an artificial thrombus more deeply than only a laser-induced bubble did. Less

由于可以检测到发作后的神经图像扩散的磁共振成像和单个光子发射的计算层造影术数小时为了改善临床应用，气泡和冲击波在临床上是Q-Switch脉冲型的通过直径为0.6 mm的光纤传播，在86 MJ/脉冲上的激光照射会在100 atm上诱导强烈的冲击波，并且可以渗透到形成射流的人造血栓中。更强的冲击波和较大的气泡，末端表面的光纤;直径为4mm的玻璃管逐渐扩展，在大约1 ms的情况下达到最大尺寸，而大容器中的气泡在大约300μs的情况下进行。尝试了iximum bubbble，将气泡转化为液体射流，该液体可以渗透到人造的人造thans中，而不是一些s someauser byced Bubble所做的