Basic Study of sound-dynamic Therapy for Atherosclerotic Cerebrovascular Disease.

动脉粥样硬化性脑血管病的声动力治疗基础研究。

• 批准号: 07557254
• 负责人: YOSHIMOTO Takashi
• 金额: $ 2.18万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557254/
• 关键词: sound-dynamic therapy; atherosclerosis; occlusive cerebrovascular diseases; shock wave; ultrasound; PTA; 閉塞性脳血栓障害; 超音波

Concomitantly with the progress of ultrasound technology in recent years, sonochemically induced cell damage (Sound-dynamic therapy) syudied various medical field, especially to treatment for cancer. In this time, these studies have demonstrated utility of sonosensitive materials (sonosensitizer) such as doxycycline (DC), hematoporphyrin and daunorubicine (DR). These results suggests that sonochemically induced cell damage by activated DC is probably mediated via sonoluminescence and by DR is probably mediated via singlet oxygen. Furthermore DC to accumulated in atheromatous plaque was excited by insonation, indicates the capability of Sound-dynamic therapy for atherosclerotic cerebrovascular disease.On the other hand, as the physical effect of ultrasound, we studied the efficacy of a liquid jet generated by the interaction of an underwater shock wave with air bubble to apply to acute fibrinolysis for cerebral embolism. Simulation studies using gelatin as embolus model and a teflon tube as a mimic vascular wall were performed. The penetration depth attained of the liquid jet was visualized by means of a high speed camera. It was suggested that the liquid jet impact induced by interaction between bubble and underwater shock waves had some potentiality as a new modality of revascularization for cerebral occlusive diseases.

近年来，与超声技术的进步同时，超声诱导的细胞损伤（声学疗法）均构成了各种医学领域，尤其是用于癌症治疗的医疗领域。在这段时间里，这些研究表明，超声敏感材料（Sonosensitizer），例如多西环素（DC），血氧霉素和daunorubicine（DR）。这些结果表明，通过激活的DC可以通过声发光介导声学诱导的细胞损伤，并且DR可能是通过单线氧介导的。此外，DC在动脉粥样硬化斑块中积累的DC被激发了，这表明了动力疗法对动脉粥样硬化脑血管疾病的能力。另一方面，作为超声的物理效应，我们研究了由液体射流产生的液体功效的能力。带有气泡的水下冲击波用于急性纤维蛋白溶解，用于脑栓栓塞。使用明胶作为栓子模型和特氟龙管作为模拟血管壁进行了模拟研究。通过高速摄像头可视化液体喷气机的渗透深度。有人提出，由于气泡和水下冲击波之间相互作用引起的液体射流影响具有一定的潜力，这是对脑闭塞性疾病的血运重建方式的一种新模式。

项目成果

Kawase M,Yoahimoto T,et al.: "Inducible nitric oxide synthase following hypoxia in rat cultured glial cells" Brain Reserch. 738. 319-322 (1996)

Kawase M、Yoahimoto T 等人：“大鼠培养的神经胶质细胞缺氧后诱导一氧化氮合酶”脑研究。

Mizoi K,Yoshimoto T,Nagamine Y: "Types of unruptured cerebral aneurysms reviewed from" Acta Neurochirurgica. 138. 965-969 (1996)

Mizoi K，Yoshimoto T，Nagamine Y：“未破裂脑动脉瘤的类型回顾自《Acta Neurochirurgica》。

Ezura M,Takahashi A,Yoshimoto T: "Evaluation of regional cerebral blood flow using single photon emission tomography for the selection of patients for local fibrinolytic therapy of acute cerebral embolism" Neurosug Rev. 19. 231-236 (1996)

Ezura M、Takahashi A、Yoshimoto T：“使用单光子发射断层扫描评估局部脑血流量，以选择接受急性脑栓塞局部纤溶治疗的患者” Neurosug Rev. 19. 231-236 (1996)

Yoshimoto T,Takanashi A,et al: "Role of embolization in the management of arteriovenous malformations" CLINICAL NEUROSURGERY. 42. 313-327 (1996)

Yoshimoto T、Takanashi A 等人：“栓塞在动静脉畸形治疗中的作用”临床神经外科。

Kamii H,Mikawa S,Murakami K,Kinouchi H,Yoshimoto T,Reola L,Carlson E,Epstein, Chan PH: "Effect of nitric oxide synthase inhibition on brain infarction in SOD-1-transgenic mice following transient19GC03 : J Cerebral Blood Flow Metabolism" 16. 1153-1157 (19

Kamii H、Mikawa S、Murakami K、Kinouchi H、Yoshimoto T、Reola L、Carlson E、Epstein、Chan PH：“一氧化氮合酶抑制对瞬时 19GC03 后 SOD-1 转基因小鼠脑梗塞的影响：J 脑血流