CLINICAL APPLICATION OF THE MEASUREMENT OF MAGNETIC FIELDS PRODUCED BY HUMAN BRAIN USING THE SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE

超导量子干涉仪测量人脑磁场的临床应用

基本信息

批准号：
63440053
负责人：
YOSHIMOTO Takashi
金额：
$ 17.98万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63440053/
关键词：
SQUID EEG MAGNETOENCEPHALOGRAPHY SLEEP SPINDLES VISUAL EVOKED POTENTIAL 睡眠紡錐波 SQUID 睡眠

项目摘要

The magnetic fields produced by electrical activities in the human brain are less weaker than those of earth. Therefore, in order to detect the brain's magnetic fields (magnetoencephalography, MEG), the superconducting quantum interference device(SQUID) is necessary. In this study, we succeeded to record the spontaneous and evoked MEG without the aid of magnetic shielding, and this is the first record in the clinical institution in Japan.First, we measured the environmental magnetic fields by a single channel dc-SQUID with a second order gradiometer (BTi, 601 Biomagnetneter) in whole day, and observed the noise spectrogram. Then, we chose midnight for recording, and the notchfilter was used to avoid the line frequency noise and its harmonics. Secondly, sleeping MEG and EEG were simultaneously recorded. Although in a previous neuromagnetic study, only few sleep spindles were recorded in MEG, we frequently observed them (especially near the central vertex). Moreover, sleep spindles were simultaneously seen in both MEG and EEG in some part of records, but in another part they were seen in either MEG or EEG only. These findings are probably due to the multiple origins of sleep spindles. Thirdly, the pattern reversal visual evoked EEG and MEG using light emitting diodes were studied. As results, a positived or negative peak in 100ms(F100) following stimulation was seen in magnetic fields, as same as a positive peak(P100) in EEG. And then, isomagnetic contour maps over occipital area for F100 component demonstrated its origin in medial areas of bilateral occipital lobes.

人脑中电活动产生的磁场不如地球弱。因此，为了检测大脑的磁场（磁脑摄影，MEG），必须使用超导量子干扰装置（squid）。在这项研究中，我们成功地记录了自发性并在无磁屏蔽的情况下唤起了MEG，这是日本临床机构中的第一个记录。首先，我们通过单个通道DC-Squid测量了环境磁场二阶渐变计（BTI，601个生物磁网表）整天观察到噪声谱图。然后，我们选择午夜进行录制，并使用Notchfilter来避免线频率噪声及其谐波。其次，同时记录了睡觉的梅格和脑电图。尽管在先前的神经磁性研究中，梅格（MEG）中只有很少的睡眠纺锤体记录，但我们经常观察到它们（尤其是在中央顶点附近）。此外，在梅格和脑电图中同时在记录的某些部分中同时看到了睡眠主轴，但是在另一部分中，它们仅在MEG或EEG中看到它们。这些发现可能是由于睡眠纺锤体的多个起源。第三，研究了使用发射二极管的模式逆转视觉唤起的脑电图和MEG。结果，在磁场中看到刺激后100ms（F100）的阳性或负峰，与EEG中的正峰（P100）相同。然后，F100组件上枕骨区域上的等磁轮廓图证明了其起源于双侧枕叶的内侧区域。