Human osteoprogenitor cells : osteoblastic phenotype and osteoblastic activity

人骨祖细胞：成骨细胞表型和成骨细胞活性

• 批准号: 08457383
• 负责人: TAKAHASHI Hideaki
• 金额: $ 4.29万
• 依托单位: NIIGATA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457383/
• 关键词: osteoprogenitor cell; CFU-F; osteoporosis; ヒト腸骨骨髄; 骨原細胞; 骨芽細胞; 細胞移植

In osteoporosis, bone formation declines with age and it may result from a decrease in the number and/or activity of osteoprogenitor cells.1. Osteoprogenitor cells are present in human iliac bone marrow.2. The number of ALP-positive CFU-F declines with age, suggesting its association with skeletal growth.3. BMP and other bone matrix related proteins mRNA are expressed.These results indicated that bone marrow stromal cells differentiate to osteoblasts.

在骨质疏松症中，骨形成随着年龄的增长而下降，这可能是由于骨祖细胞数量和/或活性下降所致。1．骨祖细胞存在于人髂骨髓中。2． ALP阳性CFU-F数量随年龄增长而下降，提示其与骨骼生长有关。3． BMP和其他骨基质相关蛋白mRNA均有表达。这些结果表明骨髓基质细胞分化为成骨细胞。

项目成果

Endo N., et al.: "Human osteoprogenitor cells express BMP1-6 and its differentiation is stimulated by BMP-2." J.Bone Miner.Res.11. s257 (1996)

Endo N. 等人：“人类骨祖细胞表达 BMP1-6，并且 BMP-2 刺激其分化。”

Endo N., et al.: "Human osteoprogenitor cells express BMP1-6 and its differentiation is stimulated by BMP-2." J.Bone Miner.Res.11. S257- (1996)

Endo N. 等人：“人类骨祖细胞表达 BMP1-6，并且 BMP-2 刺激其分化。”

N. Endo,et al.: "Human Osteoprogenitor Cells Express BMP 1-6 and Its Differentiation is Stimulated by BMP-2" Journal of Bone and Mineral Research. 11. S257 (1996)

N. Endo 等人：“人类骨祖细胞表达 BMP 1-6 及其分化受 BMP-2 刺激”《骨与矿物质研究杂志》。

Endo N., et al.: "The number of ALP-positive CFU-Fs is one of the indices exhibiting bone-forming activity in the marrowstronal cells" J.J.B.E.R.S.10. 23-25 (1996)

Endo N. 等人：“ALP 阳性 CFU-F 的数量是骨髓基质细胞中表现出骨形成活性的指标之一”J.J.B.E.R.S.10。

Endo N., et al.: "The number of ALP-positive CFU-Fs is one of the indices exhibiting bone-forming activity in the marrow stromal cells." J.J.B.E.R.S.10. 23-25 (1996)

Endo N.等人：“ALP阳性CFU-F的数量是骨髓基质细胞中表现出骨形成活性的指标之一。”