THE HISTOGENESIS OF MALIGNANT FIBROUS HISTIOCYTOMA (MFH), WITH THE SPECIAL REFERENCE TO MULTIPOTENTIAL DIFFERENTIATION OF MFH CELLS

恶性纤维组织细胞瘤(MFH)的组织发生,特别是 MFH 细胞的多向分化

基本信息

  • 批准号:
    07660424
  • 负责人:
  • 金额:
    $ 1.28万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1995
  • 资助国家:
    日本
  • 起止时间:
    1995 至 1996
  • 项目状态:
    已结题

项目摘要

The histogenesis of malignant fibrous histiocytoma (MFH) is still undetermined. We have investigated the histogenesis using cloned cell lines (MT-8, undifferentiated mesenchymal cells ; MT-9, mesenchymal cells with both natures of histiocytes and fibroblasts) derived from transplantable rat MFH.(1) By adding hyperlipemic serum or lipopolysaccharide, both which are a potential stimulus to macrophage functions, to the medium, MT-8 and MT-9 cells enhanced their histiocytic natures.(2) Cisplatin (anticancer drug)-resistant cell lines (MT-R8 and MT-R9) were induced from MT-8 and MT-9 cells, respectively. MT-R8 and MT-R9 cells enhanced both histiocytic and myofibroblastic natures, and further the tumors induced in syngeneic rats by MT-R9 cells showed a variety of histology : neoplastic proliferations of myofibroblasts and granular cells, osteosarcoma-like areas and areas involving many lipoblasts.(3) We investigated the origin of "histiocytic cells" in MFH and the immunophenotypes against ra … More t histiocyte-specific antibodies (ED1 and ED2). As a result, it was demonstrated that the presence of heterogeneities in the origin and immunophenotypes of the histiocytic cells.(4) Monoclonal antibodies against MT-8 cells were produced, and the staining patterns were immunohistochemically investigated. It was clarified that there are common antigens between MFH cells and undifferentiated mesenchymal cells or macrophage liniage cells, indicating the heterogeneity in cell natures of MFH-constituting cells.(5) We established transplantable tumors and cell lines from histiocytic sarcoma, fibrosarcoma and malignant meningioma in rats, and made comparisons of cell natures between MFH cells and these mesenchymal cell lines. The results indicated marked differences in biological natures between MFH and other mesenchymal tumor cells.(6) On the basis of these results, it was concluded that MFH consists of mesenchymal cells at various differentiation stages shifting from undifferentiated cells to cells with both histiocytic and fibroblastic natures ; the cellular natures could be easily changed, presumably depending on microenvironmental/genetic factors. MFH cells may be a mesenchymal progenitor with multipotential differentiation. The cell natures appear to contribute to endless, unstable histology of MFH.(7) Rat cell lines established in this study may provide useful experimental systems for studies on the histogenesis of MFH as well as mesenchymal differentiation yet undetermined. Less
恶性纤维组织组织(MFH)的组织发生仍未确定。我们已经使用克隆细胞系(MT-8,未分化的间充质细胞; MT-9,均具有组织细胞和成纤维细胞的生成型)来研究了组织发生。 MT-8和MT-9细胞增强了其组织细胞性质。(2)顺铂(抗癌药)抗药性细胞系(MT-R8和MT-R9)分别从MT-8和MT-9细胞诱导。 MT-R8 and MT-R9 cells enhanced both histiocytic and myofibroblastic natures, and further the tumors induced in syngeneic rats by MT-R9 cells shown a variety of histology: neoplastic proliferations of myofibroblasts and granular cells, osteosarcoma-like Areas and areas involved many lipoblasts.(3) We investigated the origin of "histiocytic cells" in MFH和针对RA的免疫表型……更多的组织细胞特异性抗体(ED1和ED2)。结果,证明了组织细胞细胞的起源和免疫表型中的异质性。(4)对MT-8细胞的单克隆抗体产生了对MT-8细胞的作用,并对染色模式进行了免疫组织化学研究。 was clarified that there are common antigens between MFH cells and undifferentiated mesenchymal cells or macrophage liniage cells, indicating the heterogeneity in cell natures of MFH-constituting cells.(5) We established transplantable tumors and cell lines from histiotic sarcoma, fibrosarcoma and malignant meningioma in rats, and made comparisons of cell natures between MFH cells这些间充质细胞系。结果表明,MFH和其他间充质肿瘤细胞之间的生物学性质显着差异。(6)在这些结果的基础上,得出的结论是,MFH由各种分化阶段组成的各种分化阶段,从未分化的细胞转移到细胞的细胞中,具有荷兰和成纤维细胞分布细胞;细胞性质可以很容易地改变,大概取决于微环境/遗传因素。 MFH细胞可能是具有多能分化的间充质祖细胞。 (7)本研究中建立的大鼠细胞系似乎有助于无尽的,不稳定的组织学,可能为MFH的组织发生以及间充质分化尚未确定尚未确定的研究提供了有用的实验系统。较少的

项目成果

期刊论文数量(18)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
yamato J: "Phenotypic modulation in cisplatin-resistant cloned cells derived from transplantable rat malignant fibrous histiocytoma" Pathology International. 46. 557-567 (1996)
yamato J:“源自可移植大鼠恶性纤维组织细胞瘤的顺铂耐药克隆细胞的表型调节”国际病理学。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Yamate J et al: "Phenotypic changes in lipopolysaccharide-treated cloned cells derived from transplantable rat malignant fibrous histiocytoma" The Journal of Veterinary Medical Science. 58. 1017-1020 (1996)
Yamate J 等人:“源自可移植大鼠恶性纤维组织细胞瘤的经脂多糖处理的克隆细胞的表型变化”《兽医医学科学杂志》。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Yamate J et al: "Phenotypic modulation in cisplatin-resistant cloned cells derived from transplantable rat malignant fibrous histiocytoma" Pathology International. 46. 557-567 (1996)
Yamate J 等人:“源自可移植大鼠恶性纤维组织细胞瘤的顺铂耐药克隆细胞的表型调节”国际病理学。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Yamate J: "Heterogeneity in the origin and immunophenotypes of "histiocytic" cells in transplantable rat malignant fibrous histiocytoma" The Journal of Veterinary Medical Science. 58. 603-609 (1996)
Yamate J:“可移植大鼠恶性纤维组织细胞瘤中“组织细胞”细胞的起源和免疫表型的异质性”《兽医医学科学杂志》。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Yamate J: "Heterogeneity in the origin and immunophenotypes of "histiocytic" cells in transplantable rat malignant fibrous histiocytoma" The Journal of Veterinary Medical Scienece. 58(in press). (1996)
Yamate J:“可移植大鼠恶性纤维组织细胞瘤中“组织细胞”细胞的起源和免疫表型的异质性”《兽医医学科学杂志》。
  • DOI:
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  • 影响因子:
    0
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YAMATE Jyoji其他文献

YAMATE Jyoji的其他文献

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{{ truncateString('YAMATE Jyoji', 18)}}的其他基金

Pathogenesis of epithelial-mesenchymal transition relating to progressing fibrosis and its clinical significance
进展性纤维化相关的上皮间质转化的发病机制及其临床意义
  • 批准号:
    23658265
  • 财政年份:
    2011
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
The pathogenesis of progressive chronic renal disease and therapeutic strategies, based on the axis of macrophages and myofibroblasts
基于巨噬细胞和肌成纤维细胞轴的进行性慢性肾病的发病机制和治疗策略
  • 批准号:
    22380173
  • 财政年份:
    2010
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Based on the relationship of macrophages-myofibroblasts, the pathogenesis of renal fibrosis and its therapeutic strategies
基于巨噬细胞与肌成纤维细胞关系的肾纤维化发病机制及治疗策略
  • 批准号:
    18380188
  • 财政年份:
    2006
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Clarification of multi-functions of macrophage populations in renal fibrosis and therapeutic strategies
阐明巨噬细胞群在肾纤维化中的多功能性和治疗策略
  • 批准号:
    15380217
  • 财政年份:
    2003
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Functional roles of macrophage populations appearing in the renal fibrosis
巨噬细胞群在肾纤维化中的功能作用
  • 批准号:
    12660287
  • 财政年份:
    2000
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Immune response at the fetal-maternal interface during normal gestation
正常妊娠期间胎儿-母体界面的免疫反应
  • 批准号:
    08045058
  • 财政年份:
    1996
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for international Scientific Research

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