Development of a method to estimate diffuse cerebral activities using multi-channel EEGs and 3D-MRI.

开发一种使用多通道 EEG 和 3D-MRI 评估弥漫性大脑活动的方法。

基本信息

批准号：
07557241
负责人：
TORU Michio
金额：
$ 2.05万
依托单位：
Tokyo Medical and Dental University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557241/
关键词：
Dipole tracing EEG MRI Corticogram MRI

项目摘要

1) Development of a multi-channel EEGs measuring method The methods and devices that digitalize EEGs of 64 channels using a computer were developed. Furthermore, we have developed a special cap that fits many electrods on scalp.2) Development of algorithm that reconstruct 3D-brain structure using digitized 3D-MRI data.Algorithm that extracts the scalp, cranium, cerebrospinal fluid cavity, cerebrum form 3D-MRI and reconstructs a 3D wire frame model was developed.3) EEG analysis on mental disorders1. EEG study on schizophrenic patients : A comparison between neuroleptic-naive state and after treatment was performed.2. Quantitative EEG correlates of normal aging in the elderly were studied.3. Estimation of epileptic source generator using dipole tracing method and 3D-MRI was performed.4. Ethanol-induced alternations in EEG was investigated as a biological marker for alcoholism.4) Development of algorithm that estimates spatially spread cerebral activityWe have developed 'Corticograma', that is a method to estimate the electrical potential of a cerebral surface from the electrical potential on the scalp. Based on this method, a electrical potential distribution of a cerebral surface was estimated based on a potential distribution of the scalp using Scalp-Skull-Cortex Model (SSB Model). The information in Corticogram increases according to the increase in the number of the electrodes attached on the scalp. The validity and error of estimation of Corticogram was evaluated.

1）开发多通道脑电图测量方法使用计算机数字化64个通道的脑电图的方法和设备。此外，我们已经开发了一个特殊的盖子，它适合许多电极。2）使用数字化的3D-MRI数据来开发算法，该算法的开发3D-脑结构。提取头皮，颅骨，脑脊液腔，大脑腔，3D-MRI 3D-MRI 3D-MRI的Algorithm并重建了一个3D电线框架模型。3）脑电图分析精神疾病1。精神分裂症患者的脑电图研究：进行神经肌动蛋白的状态和治疗后的比较。2。研究了老年人正常衰老的定量脑电图相关。3。使用偶极示踪方法和3D-MRI对癫痫源发生器进行估计4。研究了乙醇引起的脑电图作为酒精中毒的生物学标记。4）算法的开发，即估计在空间扩散的大脑活动中我们开发了“ Corticograma”，这是一种估算从电位上从电位上的电位电位的电位的方法。头皮。基于这种方法，使用头皮 - 库尔 - 皮质模型（SSB模型）根据头皮的电势分布估算了大脑表面的电势分布。皮层图中的信息根据头皮上附着的电极数量的增加而增加。评估了皮质图的估计的有效性和误差。