An Study of Development of Method for Evaluation of Brain Function Using MEEG.

利用 MEEG 评估脑功能的方法开发研究。

基本信息

批准号：
04557050
负责人：
TORU Michio
金额：
$ 8.9万
依托单位：
Faculty of Medicine, Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04557050/
关键词：
MEEG EEG Dipole-tracing MRI Eplepsy ダイポール高次脳機能

项目摘要

It was aimed to develop the way of the accurate estimation of three-dimensional dipole locations of MEEG and EEG on three-dimensional MRI.An algorithm was developed in which the estimated equivalent dipoles are interposed on the three-dimensional MRI by means of overlapping the head shape measured for a model for dipole tracing and that obtained from the reconstruction of MRI data. For the estimation of dipole locations of EEG.the shape of subject's scalp and the three-dimensional locations of the 21 electrodes used according to the 10-20 system have to be measured with a special device. The dipole tracing method on a one- or two- dipole model with a correction based on a realistic head model were adopted for the estimation od equivalent dipoles of EEG.The estimated equivalent dipoles are located on the three-dimensional MRI by means of overlapping the head shape and that obtained from the three-dimensional MRI.This algorithm is applicable in the estimation of equivalent dipoles of MEEG on precise brain anatomy.An attempt was carried out to use the developed method to estimate ictal EEG associated with epigastric aura which was incidentally observed and recorded in the case of a woman with temporal lobe epilepsy probably due to a hemangioma in the left mesial temporal lobe. The center of the equivalent dipoles during the burst of slow waves was found to be located close to the hemangioma and the lSD of the dipoles was about 10mm. This result suggests that the developed method is valid and useful for the identification of brain function on precise brain anatomy.

目的建立在三维 MRI 上准确估计 MEEG 和 EEG 三维偶极子位置的方法。提出了一种将估计的等效偶极子通过重叠三维 MRI 的方式插入到三维 MRI 上的算法。为偶极子追踪模型测量的头部形状以及从 MRI 数据重建获得的头部形状。为了估计 EEG 的偶极子位置，必须使用特殊设备测量受试者头皮的形状以及根据 10-20 系统使用的 21 个电极的三维位置。采用一偶极子模型或二偶极子模型的偶极子追踪方法，并根据真实头部模型进行校正，以估计脑电图的等效偶极子。估计的等效偶极子通过重叠三维MRI来定位。该算法适用于精确大脑解剖结构上MEEG等效偶极子的估计。尝试使用所开发的方法来估计与上腹相关的发作期EEG在一位患有颞叶癫痫的妇女身上偶然观察到并记录到的先兆，可能是由于左颞叶内侧血管瘤所致。发现慢波爆发时的等效偶极子中心位于血管瘤附近，偶极子的lSD约为10mm。这一结果表明，所开发的方法对于精确脑解剖学上识别脑功能是有效且有用的。