MRI: Acquisition of a dual-acquisition high-density EEG with transcranial electrical neuromodulation for psychophysiological research.

MRI：通过经颅电神经调节采集双采集高密度脑电图，用于心理生理学研究。

• 批准号: 2320091
• 负责人: Joshua Carlson
• 金额: $ 41.33万
• 依托单位: Northern Michigan University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320091&HistoricalAwards=false
• 关键词: MRI; Acquisition; dual; acquisition; density

This National Science Foundation Major Research Instrumentation award funds the acquisition of a high-density electroencephalogram (HD-EEG) system with high-density transcranial electric stimulation (HD-tES) neuromodulation technology and time-locked dual acquisition capabilities at Northern Michigan University (NMU). EEG is a non-invasive measure of the brain’s electrical activity with excellent (millisecond level) temporal resolution. Neuromodulation with HD-tES offers a non-invasive method of experimentally manipulating brain activity with high precision to assess the causal link between neural activation and human behavior. When two (or more) EEG devices are time-locked this method, known as hyperscanning, allows for insight into the neural mechanisms underlying social interactions. The instrumentation supported by this award is an integrated system with HD-EEG, hyperscanning EEG, and HD-tES functionality. Northern Michigan University, NMU, is a rural predominantly undergraduate institution with a large number of first-generation and low-income students. The instrumentation supported by this award will significantly enhance the research environment at NMU and in doing so provide critical training opportunities for underrepresented undergraduate students in innovative and emergent neuroscience techniques. The research supported by this award integrates across HD-EEG, hyperscanning, and HD-tES methodologies—representing a new frontier in human neuroscience research that has the potential to transform the field by testing for cause and effect brain-behavior relationships in dyadic social environments. This award supports collaborative research projects involving faculty and undergraduate students in the areas of affective and cognitive neuroscience as well as social-cogniton, behavioral, and applied fields of psychology. EEG based measures of reward processing have been extensively studied in the context of adaptive and maladaptive behavior. Yet, the underlying neural generator of these reward-based EEG signals remains a point of contention. The instrumentation supported by this award provides a unique opportunity to electrically stimulate potential neural generators via HD-tES and assess the causal effects of neuromodulation on EEG measures of reward processing. The causal effects of neuromodulation on reward processing are studied in multiple contexts including simple bidding tasks, cognitive training protocols, and operant renewal paradigms modeling relapse behavior. The research supported by this award utilizes the hyperscanning capabilities of the instrumentation to assess the neural correlates of intrinsic motivation as a function of psychological need fulfillment vs frustration via dyadic social interactions involving cooperation and competition. Hyperscanning is also used to assess differences in EEG-based measures of performance-monitoring in dyadic social environments. Studies explore the extent to which HD-tES targeting of reward processing and performance monitoring sources can be used to modulate intrinsic motivation and cooperation as well as task performance in cooperative vs competitive dyadic social interactions. In short, the research enabled by this award integrates across HD-EEG, hyperscanning, and HD-tES methodologies with the aim of better understanding the cause and effect relationship between the neural systems involved in reward processing and performance monitoring on human behavior in social contextsThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项国家科学基金会主要研究仪器奖为具有高密度经颅电刺激（HD-TES）神经调节技术和北密歇根大学（NMU）的时间锁定的双重采集能力的高密度脑电图（HD-EEG）系统的收购提供了资金。脑电图是对大脑的电活动的一种非侵入性测量，具有出色的临时分辨率（毫秒）。用HD-TES神经调节提供了一种非侵入性的方法，可以用高精度地操纵脑活动，以评估神经激活与人类行为之间的因果关系。当两个（或更多）脑电图设备被滞留时，这种方法（称为Hyperscanning）可以深入了解社交相互作用的神经机制。该奖项支持的仪器是HD-EEG，Hyperscanning EEG和HD-TES功能的集成系统。 NMU北部密歇根大学是一家艰难的本科机构，拥有大量的第一代学生和低收入学生。该奖项支持的仪器将显着增强NMU的研究环境，并为创新和新兴神经科学技术的代表性不足的本科生提供重要的培训机会。该奖项支持的研究跨越了HD-EEG，Hyperscanning和HD-TES方法，这表明了人类神经科学研究中的新领域，该研究有可能通过测试二聚体社会环境中的因果关系和影响大脑行为的关系来改变领域。该奖项支持涉及情感和认知神经科学领域的教职员工和本科生的合作研究项目，以及社会知识，行为和心理学领域。基于脑电图的奖励处理度量已在适应性和适应不良行为的背景下进行了广泛的研究。然而，这些基于奖励的脑电图信号的基本神经激源源仍然是争论的点。该奖项支持的仪器提供了一个独特的机会，可以通过HD-TES刺激潜在的神经生成剂，并评估神经调节对EEG奖励处理测量的因果影响。神经调节对奖励处理的因果影响是研究的。多个上下文，包括简单的招标任务，认知培训协议和操作更新范式建模继电器行为。该奖项支持的研究利用仪器的高压扫描能力来评估内在动机的神经自我反相，作为心理需求的函数，通过二元社交互动涉及合作和竞争，这是心理需求实现与挫败感的函数。 Hyperscanning还用于评估二元社会环境中基于脑电图的性能监测度量的差异。研究探讨了靶向奖励处理和绩效监控源的HD-TE在多大程度上可用于调节内在动机和合作以及合作中的任务绩效与竞争性二元社交互动。简而言之，该奖项的研究跨越了HD-EEG，Hyperscanning和HD-TES方法，目的是更好地理解参与奖励处理的中性系统与对人类行为的绩效监控的中性系统之间的因果关系，这反映了NSF的法定任务，这反映了通过基金会的智力评估和广泛的评估来评估，这表明了NSF的法定任务，并具有良好的评估。