Study on axonal projection of tooth-pulp driven neurons in the primary somatosensory cortex

初级体感皮层牙髓驱动神经元轴突投射的研究

• 批准号: 07457442
• 负责人: IWATA Koichi
• 金额: $ 2.69万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457442/
• 关键词: tooth pulp; diencephalon; axonal projection; cerebral cortex; 視床; 軸索終末; 視床歯髄駆動ニューロン; PHA-L; 大脳皮質第一次体性感覚野; 第一次体性感覚野; 軸索投射様式; 皮質内微小刺激; 逆方向性応答

Distribution of axons from thalamic tooth-pulp driven neurons (thalamic TPNs) in the primary somatosensory cortex (SI) were analyzed in the present study. Following three projects were provided primarily in order to clarify the cortical processing of the trigeminal nociceptive information, 1)Electrophysiological analysis of axons of the thalamic TPNs, 2)Anatomical tracing study of axons from thalamic TPNs, 3)Single axon tracing of thalamic TPNs.It was clarified in the present study that thalamic TPNs had axons distributed in the SI with clusters. It has been known that SI is organized as functional columns, which are involved in processing same sensory information. These revealed that thalamic TPNs had axons projecting to the TPNs in the different columns of the SI.The present data together with previous studies suggest that nociceptive neurons in the thalamic nuclei are able to activate SI nociceptive neurons simultaneously. The thalamocortical system as described here may be very convenient for human to escape from the noxious stimuli quickly.Single neuron tracing experiment has not successfully been done yet. However, it is believed that present study attains above-mentioned propose.

在本研究中，分析了原发性体感皮质（SI）中丘脑pulp驱动的神经元（丘脑TPN）的轴突分布。在提供三个项目之后，主要是为了阐明三叉神经伤害感受信息的皮质处理，1）丘脑TPNS轴突的电生理分析，2）丘脑TPN的轴突的解剖学跟踪研究，3）丘脑TPN的单轴突示踪。在本研究中阐明了丘脑TPN的轴突在Si中分布在Si中。众所周知，SI被组织为功能列，这些功能列与处理相同的感觉信息有关。这些表明，丘脑TPN的轴突在SI的不同列中投射到TPN。目前的数据与先前的研究一起表明，丘脑核中的伤害感受性神经元能够同时激活Si noctaptive神经元。此处描述的丘脑皮质系统对于人类迅速逃脱有害刺激可能非常方便。尚未成功完成神经元追踪实验。但是，人们认为目前的研究达到了上述提议。

项目成果

Kenji Miki, Koichi Iwata, Yoshiyuki Tsuboi, Rhyuji Sumino, Tetsuo Fukuoka, Toshiya Tachibana, Atsushi Tokunaga & Koichi Noguchi: "Response of dorsal column nuclei neurons in rats with experimental mononeuropathy." Pain. (in press). (1998)

三木贤治、岩田浩一、坪井芳之、角野隆二、福冈哲夫、立花敏也、德永敦

Koichi Iwata: "Central mechanism of nociception (in Japanese)" Sinkei Shinpo. Vol.42, No.3, (in press). (1998)

Koichi Iwata：“伤害感受的中心机制（日语）”Sinkei Shinpo。

岩田 幸一: "歯痛発現の神経処理機構について" 日本歯科東洋医学会誌. 14. 1-11 (1995)

岩田浩一：《论牙痛的神经处理机制》日本牙科东方医学会杂志 14. 1-11 (1995)。

岩田幸一: "Primary somatosensory cortical neuronal activity during the monkey's detection of the perceived change in tooth pulp stimulus intensity." Journal of Neurophysiology. (印刷中). (1998)

Koichi Iwata：“猴子检测牙髓刺激强度的感知变化期间的初级体感皮质神经元活动”（神经生理学杂志）（1998 年）。

岩田 幸一: "Response properties of primary somatosensory cortical neurons during the detection of changes in tooth pulp stimulus intensity in monkeys." Pain Research. 11(2). 125-131 (1996)

Koichi Iwata：“猴子牙髓强​​度变化的刺激检测过程中的初级体感皮层神经元的响应特性”11(2) (1996)。