Effect of emotional state induced by expectation for pain on cortical neuronal activity in awake behaving monkeys

疼痛预期诱发的情绪状态对清醒行为猴皮质神经元活动的影响

基本信息

批准号：
11470390
负责人：
IWATA Koichi
金额：
$ 9.79万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

项目摘要

In order to clarify the effect of emotional state induced by expectation for pain on cortical neuronal activity, single neuronal activities were recorded form the Primary somatosensory cortex (SI) or Anterior cingulated cortex (ACCx) and the correlation between behavior and neuronal responses were analyzed Monkeys were sitting quietly on the monkey chair. When the "Go light" conies on, monkeys press the button. Then the heat stimulus is applied to the facial skin through the thermal probe. We introduced three different types of detection trials for monkey's perceived intensity of heat stimulus intensity. 1) Heat detection: T1 temperature consists with 44-46℃ and T2 temperature is 0.2-0.8℃. Monkey need to try to detect the temperature change using a heat stimulus without light. 2) Light detection: When the monkey presses the button, L1 (basic light) comes on. After 4 to 8 second hold period, L2 (a small light intensity increment) is added on L1. Monkeys detect the change in L2 change and get reward. 3) Light detection with heat: When the monkeys press the button, L1 light comes on. With 44-46℃ heat. After 4- 8 second hold time, L2 comes on. Monkey need to detect the change in light intensity change. Many nociceptive neurons in SI and ACCx increased firing frequency following increase in stimulus temperature. When monkeys escaped from T1 before T2 coming, nociceptive neurons significantly increased their firing frequency in ACCx. The firing frequency of the S1 nociceptive neurons significantly correlated with detection latency, while ACCx neurons did not show any correlation.These suggest that SI neurons would be involved in sensory discriminative aspect of pain whereas, ACCx nociceptive neurons would be involved in motivational aspect of pain, and also nociceptive neuron sin both areas would be involved in attention of pain.

为了澄清预期疼痛对皮质神经元活动引起的情绪状态的影响，单个神经元活动被记录为主要的体感皮质（SI）或抗周期胶带皮层（ACCX）（ACCX），而行为和神经元反应之间的相关性分析了Monkey open op Moneke op Moneke open Morkey。当“灯光”固定时，猴子按下按钮。然后通过热探针将热刺激施加到面部皮肤上。我们引入了三种不同类型的检测试验，以了解猴子的热刺激强度强度。 1）热检测：T1温度以44-46℃的温度组成，T2温度为0.2-0.8℃。猴子需要尝试使用没有光的热刺激来检测温度的变化。 2）灯检测：当猴子按下按钮时，L1（基本灯）亮了。在4到8秒保持周期后，在L1上添加L2（小光强度增量）。猴子发现L2变化的变化并获得奖励。 3）用热检测光：当猴子按下按钮时，L1灯会打开。用44-46℃热。在4-8秒保持时间后，L2亮了。猴子需要检测光强度变化的变化。刺激温度升高后，SI和ACCX中的许多伤害性神经元提高了发射频率。当猴子从T2到来之前从T1逃脱时，伤害性神经元显着增加了其ACCX中的发射频率。 S1伤心神经元的发射频率与检测潜伏期显着相关，而ACCX神经元没有显示任何相关性。这些表明SI神经元将参与疼痛的感觉歧视性方面，而ACCX伤害性神经元将参与疼痛的动机方面，而伤害感受性神经元sin也将参与疼痛的关注。