Role of glutamate receptors to develop abnormal pain following trigeminal nerve injury in awake behaving monkeys

谷氨酸受体在清醒行为猴三叉神经损伤后产生异常疼痛的作用

基本信息

  • 批准号:
    17591952
  • 负责人:
  • 金额:
    $ 2.37万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2007
  • 项目状态:
    已结题

项目摘要

Two major studies were conduced in the present project, 1) awake behaving monkey study and 2) anesthetized rat study.1) In order to evaluate the neuronal mechanisms of abnormal pain in the trigeminal region, the effect of N type calcium channel blocker, ONO 2921 was systemically applied to the awake behaving monkeys with capsaicin induced hyperalgesia. The thermal detection task was trained in capsaicin treated monkeys. N type calcium was applied orally or via nasal membrane, and the thermal detection latency was measured. Heat detection latency was significantly elongated after ONO 2921 administration. The elongation of detection latency was slightly longer in oral-administrated monkeys compared with nasal-administrated monkeys. We could not any significant change in detection latency in capsaicin-untreated monkeys after ONO 2921 administration. The present results suggest that ONO 2921 have potent ability to reduce abnormal pain following capsaicin treatment in monkeys.2) The rats' model with inferior orbital nerve injury was studied how the glutamate receptors were involved in the trigeminal neuropathic pain. Rats showed reduction of escape threshold to mechanical stimulation of the face following infra-orbital nerve (ION) injury. We observed significant enhancement of neuronal activity in the trigeminal spinal subnucleus caudalis (Vc) of the rats with ION ligation. After AMPA receptor antagonist CNQX caused significant reduction of neuronal activity in this rat, but not after NMDA receptor antagonist APV or MK801 administration. These suggest that AMAP receptor is involved in trigeminal abnormal pain following trigeminal nerve injury.
在本项目中阐述了两项重大研究,1)醒着的猴子研究和2)麻醉大鼠研究。1)为了评估三叉神经区域中异常疼痛的神经元机制,N型钙通道阻滞剂的效果,Ono 2921的效果已系统地应用于与capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia capsaicia sypery capsaicia symenty syno。在经过辣椒素处理的猴子中对热检测任务进行了训练。 N型钙是口服或通过鼻膜施用的,并测量了热检测潜伏期。 ONO 2921给药后,热检测潜伏期显着拉长。与鼻腔给药的猴子相比,口腔给药的猴子的检测潜伏期伸长率略长。 Ono 2921给药后,我们无法在辣椒素未治疗的猴子中发生任何显着变化。目前的结果表明,在猴子中辣椒素治疗后,ONO 2921具有减轻异常疼痛的有效能力。2)研究的大鼠模型具有下轨道神经损伤的模型,研究了谷氨酸受体如何参与三叉神经疗法疼痛。大鼠表现出逃逸阈值的降低,从肌脱落神经(离子)损伤后对面部的机械刺激。我们观察到具有离子连接的大鼠三叉神经核颈肠下核(VC)中神经元活性的显着增强。在AMPA受体拮抗剂CNQX导致该大鼠的神经元活性显着降低,但在NMDA受体拮抗剂APV或MK801给药后,神经元活性显着降低。这些表明,三叉神经损伤后,AMAP受体参与三叉神经异常疼痛。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ca^<2+>/ calmodulin-protein kinase IIα in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transaction.
三叉神经尾部亚核中的Ca 2+ /钙调蛋白蛋白激酶IIα导致下牙槽神经交易后的神经性疼痛。
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kondo;S.;et al.;Kitagawa J;Kondo S et al.;Kondo S. et al.;Yosimichi G. et al.;Ogawa A
  • 通讯作者:
    Ogawa A
Differential responses of rostral subnucleus caudalis nad upper cervical dorsal neurons to mechanical and chemical stimulation of the parotid gland in rats.
大鼠尾侧喙亚核和上颈背神经元对腮腺机械和化学刺激的差异反应。
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Tokita;K;Inoue T.;Nakamichi Y et al.;Nakamichi Y et al.;Tsukiyama K et al.;Itoh S et al.;Yamamoto Y et al.;Udagawa N et al.;Okumura S et al.;Tsukiyama K et al.;Itoh S et al.;Yamamoto Y et al.;Udagawa N et al.;Okumura S et al.;Takahashi N et al.;Okumura S et al.;Mizoguchi T;Kobayashi Y;Kobayashi Y;Yang S;Take I;Tsuboi H;Takahashi N et al.;松本歯科大学大学院 硬組織研究グループ;Nakajima A.;Kubota I.;Suzuki I.;Nobutaka Haramoto;Kubota I;Tetsuya Kawane;Suzuki I;Shimizu K.;Ogawa A.
  • 通讯作者:
    Ogawa A.
Activation of trigeminal intranuclear pathway in rats with TMJ inflammation.
颞下颌关节炎症大鼠三叉神经核内通路的激活。
Phosphorylation of ERK in the trigeminal spinal nucleus neurons following passive jaw movement in the rats with chronic craniomandibular joint inflammation.
慢性颅下颌关节炎症大鼠被动下颌运动后三叉神经脊神经元中 ERK 的磷酸化。
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Tokita;K;Inoue T.;Nakamichi Y et al.;Nakamichi Y et al.;Tsukiyama K et al.;Itoh S et al.;Yamamoto Y et al.;Udagawa N et al.;Okumura S et al.;Tsukiyama K et al.;Itoh S et al.;Yamamoto Y et al.;Udagawa N et al.;Okumura S et al.;Takahashi N et al.;Okumura S et al.;Mizoguchi T;Kobayashi Y;Kobayashi Y;Yang S;Take I;Tsuboi H;Takahashi N et al.;松本歯科大学大学院 硬組織研究グループ;Nakajima A.;Kubota I.;Suzuki I.
  • 通讯作者:
    Suzuki I.
Mechanisms involved in modulation of trigeminal primary afferent activity in rats with peripheral mononeuropathy
  • DOI:
    10.1111/j.1460-9568.2006.05065.x
  • 发表时间:
    2006-10-01
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Kitagawa, Junichi;Takeda, Mamoru;Iwata, Koichi
  • 通讯作者:
    Iwata, Koichi
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

IWATA Koichi其他文献

IWATA Koichi的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('IWATA Koichi', 18)}}的其他基金

Comprehensive understanding of orofacial pain induced by dry mouth
全面认识口干引起的口面部疼痛
  • 批准号:
    17K11654
  • 财政年份:
    2017
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Basic measurement of biomembranes: characterization as two-dimensional reaction field
生物膜的基本测量:二维反应场的表征
  • 批准号:
    24350012
  • 财政年份:
    2012
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Involvement of glia-neuron functional interaction in intractable trigeminal neuropathic pain
神经胶质-神经元功能相互作用参与顽固性三叉神经病理性疼痛
  • 批准号:
    24659832
  • 财政年份:
    2012
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Examination of fast dynamics and hierarchical order in ionic liquids
离子液体中快速动力学和层次顺序的检查
  • 批准号:
    17073003
  • 财政年份:
    2005
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
Development of molecular spectroscopy with the use of femtosecond light pulses in the near-infrared spectral region
利用近红外光谱区飞秒光脉冲发展分子光谱
  • 批准号:
    15350005
  • 财政年份:
    2003
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Research on neuronal mechanism of trigeniinal neuropathic pain in awake behaving monkeys
清醒行为猴三叉神经痛的神经机制研究
  • 批准号:
    14571761
  • 财政年份:
    2002
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Basic measurements of partial orders in solution
解中偏序的基本测量
  • 批准号:
    12440158
  • 财政年份:
    2000
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Effect of emotional state induced by expectation for pain on cortical neuronal activity in awake behaving monkeys
疼痛预期诱发的情绪状态对清醒行为猴皮质神经元活动的影响
  • 批准号:
    11470390
  • 财政年份:
    1999
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Study on axonal projection of tooth-pulp driven neurons in the primary somatosensory cortex
初级体感皮层牙髓驱动神经元轴突投射的研究
  • 批准号:
    07457442
  • 财政年份:
    1995
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Shearing Interferometers using diffraction gratings as elements wavefront division
使用衍射光栅作为波前分割元件的剪切干涉仪
  • 批准号:
    07650056
  • 财政年份:
    1995
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似国自然基金

以聚谷氨酸—赖氨酸为基础的两性离子多肽偶联的超长效双重GIP/GLP-1受体激动剂研究
  • 批准号:
    22375177
  • 批准年份:
    2023
  • 资助金额:
    50.00 万元
  • 项目类别:
    面上项目
代谢型谷氨酸受体异源二聚体的激活机制及药理学研究
  • 批准号:
    82320108021
  • 批准年份:
    2023
  • 资助金额:
    210.00 万元
  • 项目类别:
    国际(地区)合作研究与交流项目
代谢型谷氨酸受体异源二聚体的激活机制及药理学研究
  • 批准号:
  • 批准年份:
    2023
  • 资助金额:
    210 万元
  • 项目类别:
代谢型谷氨酸受体介导酒精成瘾偏好的机制及康复研究
  • 批准号:
    82372583
  • 批准年份:
    2023
  • 资助金额:
    49 万元
  • 项目类别:
    面上项目
一种新型代谢型谷氨酸受体相关蛋白抗体的致痫性机制研究
  • 批准号:
    82371461
  • 批准年份:
    2023
  • 资助金额:
    49 万元
  • 项目类别:
    面上项目

相似海外基金

Role of intracellular metabotropic glutamate receptor 5 in persistent nociception
细胞内代谢型谷氨酸受体 5 在持续性伤害感受中的作用
  • 批准号:
    418732
  • 财政年份:
    2020
  • 资助金额:
    $ 2.37万
  • 项目类别:
    Operating Grants
Molecular Determinants of Synaptic Plasticity in Chronic Pain
慢性疼痛突触可塑性的分子决定因素
  • 批准号:
    9752685
  • 财政年份:
    2017
  • 资助金额:
    $ 2.37万
  • 项目类别:
Molecular Determinants of Synaptic Plasticity in Chronic Pain
慢性疼痛突触可塑性的分子决定因素
  • 批准号:
    10589545
  • 财政年份:
    2017
  • 资助金额:
    $ 2.37万
  • 项目类别:
Molecular Determinants of Synaptic Plasticity in Chronic Pain
慢性疼痛突触可塑性的分子决定因素
  • 批准号:
    10202744
  • 财政年份:
    2017
  • 资助金额:
    $ 2.37万
  • 项目类别:
Molecular Determinants of Synaptic Plasticity in Chronic Pain
慢性疼痛突触可塑性的分子决定因素
  • 批准号:
    9973242
  • 财政年份:
    2017
  • 资助金额:
    $ 2.37万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了