Mechanisms of hypoxic and ischemic coronary dilation

缺氧和缺血性冠状动脉扩张的机制

• 批准号: 07457167
• 负责人: ITO Takayuki
• 金额: $ 4.22万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457167/
• 关键词: hypoxia; ischemia; coronary artery; vasodilating factor; factor X; nitric oxide; reactive hyperemia; K channel

(1)Hypoxic coronary vasodilatationWe investigated potential involvement of nitric oxide, prostacyclin, adenosine, ATP sensitive K channel-opening in coronary vasodilation during 15 minutes of hypoxia in isolated rat hearts. NO greatly contributes the maintenance of the coronary flow during normoxia (40%). However, NO production is almost completely inhibited during hypoxia. Hypoxia immediately opens the K_<ATP> channels and several minutes later enhances adenosine production, thus relaxing coronary resistant vessels. Reoxygenation also dilates coronary vasculature by opening the K_<Ca> channels.Reactive hyperemiaTo clarify factors other than NO involved in reactive hyperemia after short (30sec) and a long (300sec) coronary global no-flow ischemia in isolated rat hearts. Opening of K_<ATP> channel contributes to coronary vasodilation in reactive hyperemia after short 30-sec ischemia, and opening of K_<Ca>, but not K_<ATP> channel contributes to it after long 300-sec ischemia.

（1）缺氧性冠状动脉血管扩张我们研究了一氧化氮，前列环蛋白，腺苷，ATP敏感的K通道在缺氧15分钟内在分离的大鼠心脏中缺氧15分钟内的潜在参与。在正常氧气期间（40％），没有大大贡献冠状动脉流量的维持。但是，在缺氧期间几乎没有完全抑制产量。缺氧立即打开K_ <ATP>通道，几分钟后增强了腺苷的产生，从而使冠状动脉耐药的血管松弛。重氧还可以通过打开K_ <ca>通道来扩张冠状动脉脉管系统。反应性高射精澄清因素，除了短（30秒）和长（300秒）和长（300秒）冠状动脉全球无流量缺血之后，除非参与反应性充血性血症。在短短30-SEC缺血后，K_ <ATP>通道的开放有助于反应性充血性血症的冠状动脉血管舒张，而K_ <ca>的开放率在300秒长300秒的缺血之后对此有助于K_ <ATP>通道。

项目成果

中島,義仁: "心筋の構造と代謝-1995-" 六法出版社, 6 (1996)

中岛义仁：《心肌的结构与代谢-1995-》六穗出版社，6（1996）

Masanori Shinoda: "Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts." Life Sciences. 61. 997-1007 (1997)

Masanori Shinoda：“参与冠状动脉反应性充血的钾通道类型取决于大鼠心脏先前缺血的持续时间。”

中島 義仁: "心筋の構造と代謝-1995-" 六法出版社, 6 (1996)

中岛义仁：《心肌的结构与代谢-1995-》六穗出版社，6（1996）

Masanori Shinoda, Yukio Toki, Kichiro Murase, Shinji Mokuno, Kenji Okumura, Takayuki Ito: "Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts" Life Sciences. 61. 997-1007 (1997)

Masanori Shinoda、Yukio Toki、Kichiro Murase、Shinji Mokuno、Kenji Okumura、Takayuki Ito：“参与冠状动脉反应性充血的钾通道类型取决于大鼠心脏先前缺血的持续时间”生命科学。

伊藤,隆之: "冠循環調節と病態 NOの役割" 臨床透析. 12・2. 165-170 (1996)

Ito Takayuki：“NO 在冠状动脉循环调节和病理学中的作用”临床透析 165-170（1996）。