A study of mechanism in atrial fibrillation

心房颤动的机制研究

• 批准号: 62570388
• 负责人: ITO Takayuki
• 金额: $ 1.28万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570388/
• 关键词: Atrial Fibrillation; c-GMP; ANP; Atrial Fibrillation Threshold; Atrial Pacing; Atrial Stretch; cーGMP; 心房ペーシング; 冠動脈; C-GMP

To investigate the role of cyclic nucleotides in the genesis and/or the persistence of atrial fibrillation (AF), plasma levels of cyclic GMP (c-GMP) and cyclic AMP (c-AMP) were measured in dogs with electrically induced AF. The atrial fibrillation threshold (AFT) after intravenous administration of a dibutyryl derivative of c-GMP (Dbc-GMP) on AFT were determined. Plasma levels of c-GMP, c-AMP and atrial natriuretic peptide (ANP) were also measured in patients during paroxysmal AF and sinus rhythm. The c-GMP level increased significantly 15 min after the onset of artificial AF, and gradually increased during the course of the experiment. Dbc-GMP induced a dose- dependent decrease in AFT. Clinical assessment revealed that patients had almost four times higher c-GMP and ANP levels during AF than during sinus rhythm. These results suggest that the increase in c-GMP plays an important role in the maintenance and/or the genesis of AF.Plasma concentrations of ANP and c-GMP were significantly … More correlated with mean pulmonary arterial pressure and right atrial diameter in 89 patients with heart disease. It is suggested that increased plasma concentrations of ANP were induced by increased atrial pressure as well as atrial distention in human.hANP relaxed canine coronary artery, and that increased tissue c-GMP levels in a dose-dependent fashion. The results suggest that hNAP relaxes the coronary artery by directly activating the guanylate cyclase in coronary smooth muscle.The role of intracellular signals in the regulation of ANP release was investigated using isolated rat left atria. Dibutyryl cyclic AMP and dibutyryl cyclic GMP had no effect on ANP release. Arginine vasopressin and phenylephrine stimulated ANP release dose-dependently. The ANP release stimulated by phenylephrine was inhibited by W-7, a calmodulin antagonist, and H-7, a protein kinase C inhibitor. Atrial stretch stimulated ANP release, but the release was not inhibited by W-7 or H-7. These results suggest that the mechanism responsible for stretch-induced ANP release differs from that for phenylephrine-induced ANP release. Less

为了研究自行车肽在Atreal纤颤（AF）的持久性中的作用，在具有电气诱导的AF的狗中测量了环状GMP ND循环AMP（C-AMP）的作用。在阵发性肛门节奏中，GMP，C-AMP和心房肽（ANP）也被测量。临床评估表明，患者在鼻窦节奏中的C-GMP水平几乎是SESE结果。 -GMP与89例心脏病患者中的平均肺动脉动脉压力和右心房直径相关。松弛的冠状动脉动作在冠状动脉平滑肌中激活的鸟苷酸环化酶。使用分离的大鼠左心房对ANP的调节进行了细胞内信号的作用。苯肾上腺素刺激的ANP释放是由钙调蛋白拮抗剂W-7和H-7（蛋白激酶C抑制剂H-7）遗传的。

项目成果

Kouichi Ogawa: "Pathophysiologic and prognostic considerations in circulatoryinsufficiency in congestive heart failure receptor function." Jamanese Circulation Journal. 53. 123-130 (1989)

Kouichi Okawa：“充血性心力衰竭受体功能循环不足的病理生理学和预后考虑。”

Shibata, T.;Ogawa, K., et al.: Jpn. Circ. J.50. 1091-1099 (1986)

Shibata, T.；Okawa, K. 等：Jpn。

Hainan Liang: "Correlations between serum ANF concentration and cardiac functional indices assessed by Two-Dimensional Echocardiography and Pulse Doppler method in various cardiac diseases. (Japanese)" Kokyu To Junkan 36: 1089-1094, 1988.

海南梁：“二维超声心动图和脉冲多普勒法评估各种心脏病的血清ANF浓度与心功能指标的相关性。（日文）”Kokyu To Junkan 36：1089-1094，1988。

Taketo Uno: "Increased cyclic GMP in atrial fibrillation." Journal of Electrocardiology. 19. 51-58 (1986)

Taketo Uno：“心房颤动中的循环 GMP 增加。”

Ito,T.,Toki,Y.,Needleman,P.: Proc.Natl.Acad.Sci.USA. 85. 8365-8369 (1988)

Ito,T.、Toki,Y.、Needleman,P.：Proc.Natl.Acad.Sci.USA。