Developing a cost effective Advanced Microneedle Manufacturing Process (AMMP)

开发具有成本效益的先进微针制造工艺 (AMMP)

基本信息

批准号：
576596-2022
负责人：
Dalton, ColinC
金额：
$ 2.91万
依托单位：
University of Calgary
依托单位国家：
加拿大
项目类别：
Alliance Grants
财政年份：
2022
资助国家：
加拿大
起止时间：
2022-01-01 至 2023-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=752342
关键词：
Developing cost effective Advanced Microneedle

项目摘要

Microfabricated microneedle arrays promise painless blood extraction and drug infusion by penetrating only the upper part of the skin, avoiding the nerves. This project entails the development of a scalable process of a rapid, inexpensive, manufacturing method for solid microneedles, building on preliminary proof of concept research. This grant will support the advancement of this manufacturing process to a commercializable level, wherein this novel process can be licensed and transferred to existing industries/foundries, help establish industry partnerships, or spun out into a startup company.Microfabrication methods are ideal to create solid microneedle arrays, as the materials are biocompatible, robust and designed for large-scale integration with other micro manufacturing processes. We have demonstrated a new method to make solid microneedle arrays. This project will develop the current technology into an efficient and reliable fabrication process using automated technologies, enabling new designs of large area, high-density arrays to be manufactured in a repeatable, reliable, cost efficient, and extremely timely process (devices can be made and tested the same day at speeds of ~1 microneedle per second). This project will create a new biomedical device industry, giving Alberta and Canada a competitive edge in this highly competitive area, and will lead to reduced healthcare expenditure.

微型制造的微针阵列仅穿透皮肤的上部，避开神经，从而实现无痛采血和药物输注。该项目需要在概念研究的初步验证基础上，开发一种快速、廉价的实心微针制造方法的可扩展工艺。这笔赠款将支持将这种制造工艺提升到商业化水平，其中这种新颖的工艺可以获得许可并转移到现有的行业/铸造厂，帮助建立行业合作伙伴关系，或分拆成一家初创公司。微加工方法是制造固体产品的理想选择。微针阵列，因为该材料具有生物相容性、坚固性，并且设计用于与其他微制造工艺大规模集成。我们展示了一种制造固体微针阵列的新方法。该项目将利用自动化技术将当前技术发展为高效可靠的制造工艺，从而能够以可重复、可靠、成本效益高且极其及时的工艺制造大面积、高密度阵列的新设计（可以制造器件）并在同一天以每秒约 1 根微针的速度进行测试）。该项目将创建一个新的生物医疗器械行业，使艾伯塔省和加拿大在这个竞争激烈的领域具有竞争优势，并将导致医疗保健支出减少。