Fabrication of Medical Cannula for advanced extracorporeal life support devices.

制造用于先进体外生命支持设备的医用插管。

• 批准号: 566795-2021
• 负责人: Dalton, ColinC
• 金额: $ 4.95万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=752343
• 关键词: Fabrication; Medical; Cannula; advanced; extracorporeal

Extracorporeal membrane oxygenation (ECMO), also known as extracorporeal life support (ECLS), is a technique of providing prolonged cardiac and respiratory support to persons whose heart and lungs are unable to sustain life. ECMO systems oxygenate the blood, taking over operation of the lungs and heart, allowing the organs to rest and recuperate, or while waiting for organ transplant. Current ECMO systems are bulky and complex for use in the field and are situated in hospitals ICUs (Intensive Care Units). Due to their proven lifesaving abilities, there is a strong move toward having ECMO units in ambulances. Canadian company Elsius Biomedical Corp. is developing a portable ECMO system to address this need. A crucial component of ECMO systems are the cannula, or tubes, that connect the system to the patient, enabling removal of the blood and reintroducing it back into the patient after reoxygenation. These cannulae have specific requirements to enable the ECMO process to work, such as pliability after insertion, kink resistance, long term biocompatibility, placement markers, dual lumen and flow control, to name a few, and are difficult to manufacture. Elsius is continuing a partnership with the Dalton Group to investigate, design, evaluate and develop a reliable and automated process for cannulae microfabrication which will allow Elsius to finalize their ECMO production cycle. This project will address technical challenges in the complex microfabrication process to create cannulae, by identifying and controlling key process variables such as cannulae geometry, coating temperature and dipping time, to ensure uniform layering. Once optimized, the process will be automated to create a repeatable and reliable manufacturing process. There are currently no cannulae manufacturers in Canada. As cannulae can be used in other medical situations, like cardiac surgery and neurosurgery, this engineering solution will result in many benefits to the Canadian Healthcare system.

体外膜肺氧合（ECMO），也称为体外生命支持（ECLS），是一种为心肺无法维持生命的人提供长期心脏和呼吸支持的技术。 ECMO 系统为血液供氧，接管肺和心脏的运作，让器官休息和恢复，或在等待器官移植时。目前的 ECMO 系统体积庞大且复杂，无法在现场使用，并且位于医院 ICU（重症监护病房）中。由于 ECMO 的救生能力已得到证实，因此在救护车上配备 ECMO 装置的趋势非常明显。加拿大公司 Elsius Biomedical Corp. 正在开发便携式 ECMO 系统来满足这一需求。 ECMO 系统的一个重要组成部分是将系统连接到患者的插管或管道，能够排出血液并在再氧合后将其重新引入患者体内。这些插管具有使 ECMO 过程发挥作用的特定要求，例如插入后的柔韧性、抗扭结性、长期生物相容性、放置标记、双腔和流量控制等，并且难以制造。 Elsius 继续与道尔顿集团合作，研究、设计、评估和开发可靠的自动化插管微加工工艺，这将使 Elsius 能够最终确定其 ECMO 生产周期。该项目将通过识别和控制关键工艺变量（例如插管几何形状、涂层温度和浸渍时间）来解决创建插管的复杂微加工过程中的技术挑战，以确保均匀分层。一旦优化，该过程将实现自动化，以创建可重复且可靠的制造过程。目前加拿大没有插管制造商。由于插管可用于其他医疗情况，例如心脏手术和神经外科，因此这种工程解决方案将为加拿大医疗保健系统带来许多好处。