A new biomechanical model for understanding aging of stored Red Blood Cells

用于了解储存红细胞老化的新生物力学模型

• 批准号: LP150100737
• 负责人: Prof Yuantong Gu
• 金额: $ 24.35万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-10-22 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP150100737
• 关键词: new; biomechanical; model; understanding; aging

This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent correlations. It should provide new insights and understanding of the mechanisms of deformability changes of RBCs during stored lifespan. Therefore, it should significantly improve blood storage industry practices in terms of improving RBC storage protocols with preventative ageing strategies.

该项目计划开发一个新颖的建模框架，以准确地代表在存储条件下随着时间的推移，随着时间的推移，红细胞（RBC）的生物力学特性。储存的RBC遭受与年龄相关的变形性变化，这会阻碍RBC功能。该框架旨在整合RBC膜，血红蛋白内部和外部存储解决方案的模型，并通过嵌入时间相关的相关性来解释衰老效应。它应该提供新的见解，并了解储存寿命期间RBC变形的机制。因此，它应该显着改善血液储存行业的实践，以改善使用预防性衰老策略的RBC存储协议。