A Multiscale Modelling Framework for Mechanical Properties of ECM

ECM 机械性能的多尺度建模框架

• 批准号: DP150100828
• 负责人: Prof Yuantong Gu
• 金额: $ 24.5万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100828
• 关键词: Multiscale; Modelling; Framework; Mechanical; Properties

This project aims to develop a novel hierarchical multi-scale modelling framework to understand factors that influence the mechanical deformation behaviour of the extracellular matrix (ECM) such as cartilage, whose mechanical performance is critical to human wellbeing. Modelling ECM presents significant challenges due to the need to incorporate effects at scales from atomic interactions up to the fibre network in a continuum model. The proposed framework follows ECM's natural hierarchical structure and integrates efficient models for each key structural scale based on rigorous experimental validations. It is expected to provide a powerful tool for designing successful artificial ECM materials and understanding the mechanisms of the ECM degradation.

该项目旨在开发一种新型的层次多尺度建模框架，以了解影响细胞外基质（ECM）的机械变形行为（例如软骨）的因素，软骨的机械性能对人类的健康至关重要。建模ECM提出了重大挑战，因为需要在连续模型中纳入从原子相互作用到光纤网络的量表。提出的框架遵循ECM的自然层次结构，并基于严格的实验验证，为每个关键结构尺度的有效模型整合了有效的模型。预计它将提供一个强大的工具，用于设计成功的人工ECM材料并了解ECM降解的机制。