Articular Cartilage Formation by Continuous Joint Movement with External Fixato

通过外固定器持续关节运动形成关节软骨

• 批准号: 03557062
• 负责人: ODA Hiromi
• 金额: $ 10.94万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03557062/
• 关键词: Cartilage formation; External fixator; Continuous Joint Movement; Distraction force; 創外固定器; 関節形成術; 圧迫力; 関節造成システム; CPM; 軟骨形成; 関節形成; 持続他動運動

It is generaly accepted that cartilage regeneration is very difficult. The purpose of this research project is to develop the methods for cartilage regeneration. We performed three basic type of experiments.Experiment 1. After all of the cartilage material was removed from rabbit knee joints, continuous passive movement was applied to the joints by using external fixators under contact, or non-contact, conditions. Eight weeks later, hyaline cartilage were made only under non-contact conditions.Experiment 2.3 mm diameter defects were created surgically in the femoral condyles of rabbit knee joints. External fixators were attached around the joints and active movement was allowed under both contact, and non-contact, conditions. Four weeks later, cartilage regeneration had occurred, only under non-contact conditions.Experiment 3. Distraction force was applied to rabbit knee joints, using external fixators. Cartilage degeneration occurred nine weeks later.From these results, we conclude, that continuous movement, under non-contact condition, is necessary for cartilage regeneration, and commpressive force is necessary for maintaining normal cartilage function.

普遍认为，软骨再生非常困难。该研究项目的目的是开发软骨再生的方法。我们进行了三种基本的实验类型。实验1。从兔膝关节中除去所有软骨材料后，通过使用接触或非接触条件的外部固定器将连续的被动运动应用于关节。八周后，仅在非接触条件下制成透明软骨。体验2.3 mm直径缺陷，在兔膝关节的股骨con虫中产生。在接触和非接触条件下允许外固定器附着在关节周围，并允许主动运动。四个星期后，仅在非接触条件下发生软骨再生。经验3。使用外部固定器将干扰力施加到兔膝关节上。软骨变性发生了九周后。从这些结果起，我们得出结论，在非接触条件下连续运动对于软骨再生是必不可少的，并且要保持正常的软骨功能是必要的。

项目成果

Shin-Chieh Hunger al.: "Effect of Contimous Distraction on Cartilage in a Moving Joint" Journal of Orthopaedic Research. 15. 381-390 (1997)

Shin-Chieh Hunger 等人：“连续分散对运动关节软骨的影响”骨科研究杂志。