The effect mechanical status on the repair of cartilage injury transplanted with cultured chondrocytes

力学状态对培养软骨细胞移植软骨损伤修复的影响

• 批准号: 07457327
• 负责人: TAKESHITA Katusi
• 金额: $ 4.8万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457327/
• 关键词: cartilage injury; external fixator; knee joint; 膝関節; 自動運動; 自家培養軟骨細胞; 軟骨欠損修復; 力学的環境; 軟骨細胞; 移植; 軟骨欠損

To investigate the effect of the load and the motion of the joint on the repair of the cartilage injury. we newly developed the external fixater for the rabbit which could eliminate the load of the joint and permit the active motion. We prepared the full thickness cartilage defect in the femoral condyle of the rabbits and applied the external fixater for 4 weeks and examined the repair tissue histologically after 8 weeks. The relief of the joint load with the active motion was showed to effect the cartilage repair beneficially compared with the relief of the joint load without joint motion or the permission of the joint load with the active motion. Surrounding normal cartilage was not influenced by the aplication of the apparatus. We could not find the beneficial effect of transplantation of cartilage cells on the cartilage repair due to the early dislodgement of the cartilage cells collagen graft. These results suggested the possibility of the improvement of the joint cartilage repair by means of the control of the mechanical status of the joint.

研究负载和关节运动对软骨损伤修复的影响。我们新开发了兔子外固定器，可以消除关节负荷并允许主动运动。我们制备了家兔股骨髁全层软骨缺损，应用外固定器4周，8周后对修复组织进行组织学检查。与不进行关节运动而减轻关节负荷或允许主动运动来减轻关节负荷相比，通过主动运动来减轻关节负荷对软骨修复有利。周围正常软骨不受装置应用的影响。由于软骨细胞胶原蛋白移植物的早期脱落，我们无法发现软骨细胞移植对软骨修复的有益效果。这些结果表明通过控制关节的机械状态来改善关节软骨修复的可能性。

项目成果

Ryozi Shiro, Takahide Kurokawa, et al.: "Experimental study of cartilage repair by the control of the joint motion" J.Jpn.Orthop.Assoc. 69 (8). (1995)

Ryozi Shiro、Takahide Kurokawa 等：“通过控制关节运动进行软骨修复的实验研究”J.Jpn.Orthop.Assoc。

城 良二, 黒川 高秀 ら: "関節運動による軟骨修復の試み" 日本整形外科科学会誌. 69(8). 1279-1279 (1995)

Ryoji Jo、Takahide Kurokawa 等人：“尝试通过关节运动修复软骨”，日本骨科学会杂志 69(8) 1279-1279 (1995)。

城 良二、黒川高秀ら: "関節運動による軟骨修復の試み" 日本整形外科学会誌. 69(8). 1279-1279 (1995)

Ryoji Jo、Takahide Kurokawa 等人：“尝试通过关节运动修复软骨”，日本骨科学会杂志 69(8) 1279-1279 (1995)。