DEVELOPMENT OF PERCUTANEOUS DEVICES MADE OF SINTERED HYDROXYAPATITE FOR THE DISABLE ELDERLY

残疾老年人用烧结羟基磷灰石经皮器械的研制

• 批准号: 03557051
• 负责人: TSUJI Takayuki
• 金额: $ 4.99万
• 依托单位: NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE (1993)Tokyo Medical and Dental University (1991-1992)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03557051/
• 关键词: hyroxyapatite; skin button; percutaneous device; the disable elderly; nasogastric tube feeding; incontinence; QOL; biomaterial; ハイドロキシアパタイト皮膚端子; 小腸瘻; らせんカテーテル; 存宅医療; 医用材料; らせんカテ-テル; 在宅医療; PVAマイクロポ-ラスカテ-テル

Percutaneous devices consisting sintered hydroxyapatite skin button and silastic connecting tubes were developed for improvement of daily activities of the disabled elderly mainly because of neurological diseases who cannot orally eat by themselves, or have urinal incontinence.Three patients having been fed through nasogastric tubing were operatively implanted with the percutaneous devices for enteric fistula. They all were successfully fed through the fistula but enteric feeding ended in interruption within 3 months because of the denuded skin button flange due to misadaptation to the overlying skinTwo young pigs were implanted in their neck with the percutaneous devices connecting the bladder with a silastic tube underlying the skin for cystic fistula. Urine drainage through the devices was failed in 2 and months later, respectively, because of occlusion of tube with urine stone formation.An intraperitoneal indwelling catheter consisting of blind-ended microporous PVA hollow fiber and PVC tubing and having the skin button was developed for daily injection site of insulin especially for the aged diabetics.In conclusion, improvement of the device design and development of new material resistant to urine stone formation in the bladder are necessary. Further research has to be carried out for better QOL of the disabled elderly.

为改善因神经系统疾病而不能自行进食或小便失禁的老年人的日常活动能力，开发了由烧结羟基磷灰石皮扣和硅橡胶连接管组成的经皮装置。对3名通过鼻胃管喂养的患者进行了手术植入与经皮肠瘘装置。它们均通过瘘管成功喂养，但肠喂养在 3 个月内终止，原因是由于与覆盖的皮肤不适应而导致皮肤按钮凸缘裸露。在两只幼猪的颈部植入经皮装置，将膀胱与下方的硅橡胶管连接起来皮肤囊性瘘管。由于尿石形成导致管子堵塞，通过该装置的尿液引流分别在 2 个月和几个月后失败。开发了一种由盲端微孔 PVA 中空纤维和 PVC 管组成并具有皮扣的腹腔留置导管，用于日常使用胰岛素的注射部位，特别是对于老年糖尿病患者。 总之，有必要改进设备设计并开发抵抗膀胱尿结石形成的新材料。为了提高残疾老年人的生活质量，还需要开展进一步的研究。

项目成果

辻隆之,井筒岳,本保秀三,ほか: "アセスメント皮膚端子の経腸栄養用空腸瘻3症例への応用とその問題点" 生体材料. 10. 256-260 (1992)

Takayuki Tsuji、Gaku Izutsu、Hidezo Honyasu 等人：“评估皮肤终端在肠内营养空肠造口术及其问题的三例中的应用”生物材料。 10. 256-260 (1992)

辻 隆之ほか5名: "テイルフィン付き水晶温度センサの開発と超音波法による臓器血流推定法の実験的検討" 臨床体温. 14(1). 85-89 (1994)

Takayuki Tsuji 等 5 人：“带有尾鳍的晶体温度传感器的开发和使用超声方法的器官血流估计方法的实验研究”临床体温 14(1) (1994)。

辻 隆之: "超微細管粘度計測法とアルブミン分子の変形性" 第17回大阪大学BME研究会コロキアム. 27-30 (1994)

Takayuki Tsuji：“超细管粘度测量方法和白蛋白分子的变形性”第17届大阪大学BME研究小组讨论会27-30（1994）。

辻 隆之ほか4名: "超微細管粘度計測法による蛋白希薄溶液の超微細管流動" 第3回バイオエンジニアリングシンポジウム. 124-125 (1994)

Takayuki Tsuji等4人：“使用超细管粘度测量方法的稀蛋白质溶液的超细管流动”第3届生物工程研讨会124-125（1994）。

辻 隆之,戸川 達男: "腹腔内留置用らせんカテ-テルの開発と腹水再還流療法への臨床応用経験" 日本医科器械学誌. 62. (1992)

Takayuki Tsuji，Tatsuo Tokawa：“腹腔内放置螺旋导管的开发和腹水再灌注治疗的临床应用经验”日本医疗器械杂志 62。（1992）。