DEVELOPMENT OF PERCUTANEOUS DEVICES MADE OF SINTERED HYDROXYAPATITE FOR THE DISABLE ELDERLY

残疾老年人用烧结羟基磷灰石经皮器械的研制

• 批准号: 03557051
• 负责人: TSUJI Takayuki
• 金额: $ 4.99万
• 依托单位: NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE (1993)Tokyo Medical and Dental University (1991-1992)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03557051/
• 关键词: hyroxyapatite; skin button; percutaneous device; the disable elderly; nasogastric tube feeding; incontinence; QOL; biomaterial; ハイドロキシアパタイト皮膚端子; 小腸瘻; らせんカテーテル; 存宅医療; 医用材料; らせんカテ-テル; 在宅医療; PVAマイクロポ-ラスカテ-テル

Percutaneous devices consisting sintered hydroxyapatite skin button and silastic connecting tubes were developed for improvement of daily activities of the disabled elderly mainly because of neurological diseases who cannot orally eat by themselves, or have urinal incontinence.Three patients having been fed through nasogastric tubing were operatively implanted with the percutaneous devices for enteric fistula. They all were successfully fed through the fistula but enteric feeding ended in interruption within 3 months because of the denuded skin button flange due to misadaptation to the overlying skinTwo young pigs were implanted in their neck with the percutaneous devices connecting the bladder with a silastic tube underlying the skin for cystic fistula. Urine drainage through the devices was failed in 2 and months later, respectively, because of occlusion of tube with urine stone formation.An intraperitoneal indwelling catheter consisting of blind-ended microporous PVA hollow fiber and PVC tubing and having the skin button was developed for daily injection site of insulin especially for the aged diabetics.In conclusion, improvement of the device design and development of new material resistant to urine stone formation in the bladder are necessary. Further research has to be carried out for better QOL of the disabled elderly.

开发了烧结的羟基磷灰石皮肤纽扣和索尔斯特连接管的经皮设备，以改善残疾老年人的日常活动，主要是因为神经系统疾病无法自行口服或尿液失毒。他们都成功地通过瘘管喂食，但由于对上覆的skintwo年轻猪的不幸，将肠子喂食在3个月内因裸露的纽扣法兰而告终，将其颈部植入了脖子上，经皮具将丝状管与丝状管连接起来，以使皮肤上的皮肤上的丝状管连接起来，以使囊肿叶骨上囊肿。由于用尿液形成抑制管子，分别在两个月和几个月后分别失败了尿液。腹膜内的嵌入式导管由盲目的微孔微孔PVA空心纤维和PVC管组成，并具有针对新材料的每日胰岛素的胰岛素，尤其是针对胰岛素的胰岛素及时开发的，尤其是胰岛素的纯正工具。在膀胱中是必要的。必须进行进一步的研究，以使残疾老年人更好。

项目成果

辻隆之,井筒岳,本保秀三,ほか: "アセスメント皮膚端子の経腸栄養用空腸瘻3症例への応用とその問題点" 生体材料. 10. 256-260 (1992)

Takayuki Tsuji、Gaku Izutsu、Hidezo Honyasu 等人：“评估皮肤终端在肠内营养空肠造口术及其问题的三例中的应用”生物材料。 10. 256-260 (1992)

辻 隆之ほか5名: "テイルフィン付き水晶温度センサの開発と超音波法による臓器血流推定法の実験的検討" 臨床体温. 14(1). 85-89 (1994)

Takayuki Tsuji 等 5 人：“带有尾鳍的晶体温度传感器的开发和使用超声方法的器官血流估计方法的实验研究”临床体温 14(1) (1994)。

辻 隆之: "超微細管粘度計測法とアルブミン分子の変形性" 第17回大阪大学BME研究会コロキアム. 27-30 (1994)

Takayuki Tsuji：“超细管粘度测量方法和白蛋白分子的变形性”第17届大阪大学BME研究小组讨论会27-30（1994）。

辻 隆之,戸川 達男: "腹腔内留置用らせんカテ-テルの開発と腹水再還流療法への臨床応用経験" 日本医科器械学誌. 62. (1992)

Takayuki Tsuji，Tatsuo Tokawa：“腹腔内放置螺旋导管的开发和腹水再灌注治疗的临床应用经验”日本医疗器械杂志 62。（1992）。

辻 隆之ほか4名: "超微細管粘度計測法による蛋白希薄溶液の超微細管流動" 第3回バイオエンジニアリングシンポジウム. 124-125 (1994)

Takayuki Tsuji等4人：“使用超细管粘度测量方法的稀蛋白质溶液的超细管流动”第3届生物工程研讨会124-125（1994）。